Publication: Induction of protective immunity against infection by Angiostrongylus cantonensis in rats
Issued Date
1985-01-01
Resource Type
ISSN
00383619
Other identifier(s)
2-s2.0-0021849048
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Mahidol University
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SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.16, No.1 (1985), 31-40
Suggested Citation
A. Dharmkrong-at, S. Sirisinha Induction of protective immunity against infection by Angiostrongylus cantonensis in rats. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.16, No.1 (1985), 31-40. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/30873
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Title
Induction of protective immunity against infection by Angiostrongylus cantonensis in rats
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Abstract
Attempts were made to induce acquired immunity against Angiostrongylus cantonensis infection by immunizing rats with somatic (L3S) and metabolic (L3ES) antigens from third-stage larvae and with somatic antigen from adult female worms (FACE) via either a combined intraperitoneal and oral (IP-OR-OR) or subcutaneous (SC-SC-SC) route. The most effective mean in inducing protection was the administration of L3S by the IP-OR-OR route, as judged from reduced mortality, prolonged survival periods and/or reduced worm burdens. Such a protocol reduced mortality to below 20% of the immunized controls. The worm burden of the L3S-immunized rats was only about 25% of the control value and the survival period was at least double. However, judging from gross morphology, the absence of stunted growth and unimpaired ficundity of the worms that developed into adult stage, it appears that those worms that survived had normal development. The latter observation is in contrast to that noted with FACE immunization which seemed to affect also the growth and development of worms that survived into adult stage.