Publication:
In-hospital mortality of hepatorenal syndrome in the United States: Nationwide inpatient sample

Issued Date

2021-12-07

Resource Type

Article

ISSN

22192840
10079327

DOI

10.3748/wjg.v27.i45.7831

Other identifier(s)

2-s2.0-85121822747

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

World Journal of Gastroenterology. Vol.27, No.45 (2021), 7831-7843

Suggested Citation

Wisit Kaewput, Charat Thongprayoon, Carissa Y. Dumancas, Swetha R. Kanduri, Karthik Kovvuru, Chalermrat Kaewput, Pattharawin Pattharanitima, Tananchai Petnak, Ploypin Lertjitbanjong, Boonphiphop Boonpheng, Karn Wijarnpreecha, Jose L. Zabala Genovez, Saraschandra Vallabhajosyula, Caroline C. Jadlowiec, Fawad Qureshi, Wisit Cheungpasitporn In-hospital mortality of hepatorenal syndrome in the United States: Nationwide inpatient sample. World Journal of Gastroenterology. Vol.27, No.45 (2021), 7831-7843. doi:10.3748/wjg.v27.i45.7831 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/77408

Research Projects

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Title

In-hospital mortality of hepatorenal syndrome in the United States: Nationwide inpatient sample

Author(s)

Wisit Kaewput
 Charat Thongprayoon
 Carissa Y. Dumancas
 Swetha R. Kanduri
 Karthik Kovvuru
 Chalermrat Kaewput
 Pattharawin Pattharanitima
 Tananchai Petnak
 Ploypin Lertjitbanjong
 Boonphiphop Boonpheng
 Karn Wijarnpreecha
 Jose L. Zabala Genovez
 Saraschandra Vallabhajosyula
 Caroline C. Jadlowiec
 Fawad Qureshi
 Wisit Cheungpasitporn

Other Contributor(s)

Ramathibodi Hospital
 Siriraj Hospital
 Wake Forest University School of Medicine
 Mayo Clinic Scottsdale-Phoenix, Arizona
 University of Michigan, Ann Arbor
 Ochsner Health System
 University of Washington
 Faculty of Medicine, Thammasat University
 Phramongkutklao College of Medicine
 Mayo Clinic
 University of Tennessee Health Science Center

Abstract

BACKGROUND Hepatorenal syndrome (HRS) is a life-threatening condition among patients with advanced liver disease. Data trends specific to hospital mortality and hospital admission resource utilization for HRS remain limited. AIM To assess the temporal trend in mortality and identify the predictors for mortality among hospital admissions for HRS in the United States. METHODS We used the National Inpatient Sample database to identify an unweighted sample of 4938 hospital admissions for HRS from 2005 to 2014 (weighted sample of 23973 admissions). The primary outcomes were temporal trends in mortality as well as predictors for hospital mortality. We estimated odds ratios from multilevel mixed effect logistic regression to identify patient characteristics and treatments associated with hospital mortality. RESULTS Overall hospital mortality was 32%. Hospital mortality decreased from 44% in 2005 to 24% in 2014 (P < 0.001), while there was an increase in the rate of liver transplantation (P = 0.02), renal replacement therapy (P < 0.001), length of hospital stay (P < 0.001), and hospitalization cost (P < 0.001). On multivariable analysis, older age, alcohol use, coagulopathy, neurological disorder, and need for mechanical ventilation predicted higher hospital mortality, whereas liver transplantation, transjugular intrahepatic portosystemic shunt, and abdominal paracentesis were associated with lower hospital mortality. CONCLUSION Although there was an increase in resource utilizations, hospital mortality among patients admitted for HRS significantly improved. Several predictors for hospital mortality were identified.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/77408

Collections

Scopus 2021