Publication: Artemisinin derivatives in the treatment of falciparum malaria in pregnancy
Issued Date
1998-01-01
Resource Type
ISSN
00359203
Other identifier(s)
2-s2.0-0031685237
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.92, No.4 (1998), 430-433
Suggested Citation
Rose McGready, Thein Cho, Ju Ju Cho, Julie A. Simpson, Christine Luxemburger, Lilly Dubowitz, Sornchai Looareesuwan, Nicholas J. White, Francois Nosten Artemisinin derivatives in the treatment of falciparum malaria in pregnancy. Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.92, No.4 (1998), 430-433. doi:10.1016/S0035-9203(98)91081-1 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/18425
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Artemisinin derivatives in the treatment of falciparum malaria in pregnancy
Other Contributor(s)
Abstract
An artemisinin derivative (artesunate or artemether) was used for the treatment of multidrug-resistant Plasmodium falciparum malaria in 83 Karen pregnant women in Thailand; 55 women were treated for recrudescent infection following quinine or mefloquine, 12 for uncomplicated hyperparasitaemic episodes, and 16 had not declared their pregnancy when created. The women were followed weekly until delivery. Artesunate and artemether were well tolerated and there was no drug-related adverse effect. Recrudescence within 42 d occurred in 16% of the treated episodes. Overall 73 pregnancies (88%) resulted in live births, 3 (4%) in abortions and 2 (3%) in still births, and 5 women were lost to follow-up before delivery. There was no congenital abnormality in any of the newborn children, and the 46 children followed for more than one year all developed normally.