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Use of nonlinear mixed-effects analysis for improved precision of early pharmacodynamic measures in tuberculosis treatment

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dc.contributor.authorGeraint R. Daviesen_US
dc.contributor.authorRichard Brindleen_US
dc.contributor.authorSaye H. Khooen_US
dc.contributor.authorLeon J. Aaronsen_US
dc.contributor.otherUniversity of Liverpoolen_US
dc.contributor.otherPortsmouth Hospitalsen_US
dc.contributor.otherUniversity of Manchesteren_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-08-20T07:12:52Z
dc.date.available2018-08-20T07:12:52Z
dc.date.issued2006-09-01en_US
dc.description.abstractNonlinear mixed-effects analysis of serial sputum colony-counting data supports the existence of two bacillary subpopulations in sputum, eliminated at different rates. It distinguishes between combination regimens, removes bias, and greatly improves precision, with significant implications for the analysis of surrogate endpoints of "sterilization" in the development of new antituberculosis regimens. Copyright © 2006, American Society for Microbiology. All Rights Reserved.en_US
dc.identifier.citationAntimicrobial Agents and Chemotherapy. Vol.50, No.9 (2006), 3154-3156en_US
dc.identifier.doi10.1128/AAC.00774-05en_US
dc.identifier.issn00664804en_US
dc.identifier.other2-s2.0-33748685468en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/23635
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33748685468&origin=inwarden_US
dc.subjectMedicineen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleUse of nonlinear mixed-effects analysis for improved precision of early pharmacodynamic measures in tuberculosis treatmenten_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33748685468&origin=inwarden_US

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