Publication: Amides and flavonoids from the fruit and leaf extracts of melodorum siamensis
Issued Date
2019-02-22
Resource Type
ISSN
15206025
01633864
01633864
Other identifier(s)
2-s2.0-85061291220
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Natural Products. Vol.82, No.2 (2019), 283-292
Suggested Citation
Wuttichai Jaidee, Raymond J. Andersen, Miguel A.G. Chavez, Yan A. Wang, Brian O. Patrick, Stephen G. Pyne, Chatchai Muanprasat, Suparerk Borwornpinyo, Surat Laphookhieo Amides and flavonoids from the fruit and leaf extracts of melodorum siamensis. Journal of Natural Products. Vol.82, No.2 (2019), 283-292. doi:10.1021/acs.jnatprod.8b00696 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/50251
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Title
Amides and flavonoids from the fruit and leaf extracts of melodorum siamensis
Abstract
© 2019 American Chemical Society and American Society of Pharmacognosy. Four new chalcones (1, 10, 13, and 14), a new flavanone, (9), a new amide (8), and 19 known compounds were acquired from Melodorum siamensis. The structures were established by NMR and MS data analyses. Compounds 1 (er 1.4:1) and 2 (er 1.1:1) were scalemic and were resolved to yield -1 and (+)-1 and -2 and (+)-2, respectively. The absolute configurations of these compounds were determined from experimental and calculated ECD data. The structures and configurations of -2 and (+)-8 were identified by single-crystal X-ray diffraction analysis. Compound 11 showed nuclear factor-B inhibitory effects (IC 50 = 9 μM) in a pancreatic β cell line (MIN-6 cells).