Publication:
Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine

Issued Date

2021-11-11

Resource Type

Article

ISSN

10974172
00928674

DOI

10.1016/j.cell.2021.10.011

Other identifier(s)

2-s2.0-85118834382

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Cell. Vol.184, No.23 (2021), 5699-5714.e11

Suggested Citation

Rebecca P. Payne, Stephanie Longet, James A. Austin, Donal T. Skelly, Wanwisa Dejnirattisai, Sandra Adele, Naomi Meardon, Sian Faustini, Saly Al-Taei, Shona C. Moore, Tom Tipton, Luisa M. Hering, Adrienn Angyal, Rebecca Brown, Alexander R. Nicols, Natalie Gillson, Susan L. Dobson, Ali Amini, Piyada Supasa, Andrew Cross, Alice Bridges-Webb, Laura Silva Reyes, Aline Linder, Gurjinder Sandhar, Jonathan A. Kilby, Jessica K. Tyerman, Thomas Altmann, Hailey Hornsby, Rachel Whitham, Eloise Phillips, Tom Malone, Alexander Hargreaves, Adrian Shields, Ayoub Saei, Sarah Foulkes, Lizzie Stafford, Sile Johnson, Daniel G. Wootton, Christopher P. Conlon, Katie Jeffery, Philippa C. Matthews, John Frater, Alexandra S. Deeks, Andrew J. Pollard, Anthony Brown, Sarah L. Rowland-Jones, Juthathip Mongkolsapaya, Eleanor Barnes, Susan Hopkins, Victoria Hall, Christina Dold, Christopher J.A. Duncan, Alex Richter, Miles Carroll, Gavin Screaton, Thushan I. de Silva, Lance Turtle, Paul Klenerman, Susanna Dunachie, Hibatullah Abuelgasim, Emily Adland, Syed Adlou, Hossain Delowar Akther, Ahmed Alhussni, Mohammad Ali, M. Azim Ansari, Carolina V. Arancibia-Cárcamo, Martin Bayley, Helen Brown, Jeremy Chalk, Meera Chand, Anu Chawla, Senthil Chinnakannan, Jospeh Cutteridge, Catherine de Lara, Lucy Denly, Ben Diffey, Stavros Dimitriadis, Thomas M. Drake, Timothy Donnison, Maeva Dupont, David Eyre, Alex Fairman, Siobhan Gardiner, Javier Gilbert-Jarmillo, Philip Goulder, Carl Philipp Hackstein, Sophie Hambleton, Muzlifah Haniffa, Jenny Haworth, Jennifer Holmes, Emily Horner, Anni Jämsén, Chris Jones, Mwila Kasanyinga, Sinead Kelly, Rosemary Kirk, Michael L. Knight, Allan Lawrie, Lian Lee Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine. Cell. Vol.184, No.23 (2021), 5699-5714.e11. doi:10.1016/j.cell.2021.10.011 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/75958

Research Projects

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Thesis

Title

Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine

Author(s)

Rebecca P. Payne
 Stephanie Longet
 James A. Austin
 Donal T. Skelly
 Wanwisa Dejnirattisai
 Sandra Adele
 Naomi Meardon
 Sian Faustini
 Saly Al-Taei
 Shona C. Moore
 Tom Tipton
 Luisa M. Hering
 Adrienn Angyal
 Rebecca Brown
 Alexander R. Nicols
 Natalie Gillson
 Susan L. Dobson
 Ali Amini
 Piyada Supasa
 Andrew Cross
 Alice Bridges-Webb
 Laura Silva Reyes
 Aline Linder
 Gurjinder Sandhar
 Jonathan A. Kilby
 Jessica K. Tyerman
 Thomas Altmann
 Hailey Hornsby
 Rachel Whitham
 Eloise Phillips
 Tom Malone
 Alexander Hargreaves
 Adrian Shields
 Ayoub Saei
 Sarah Foulkes
 Lizzie Stafford
 Sile Johnson
 Daniel G. Wootton
 Christopher P. Conlon
 Katie Jeffery
 Philippa C. Matthews
 John Frater
 Alexandra S. Deeks
 Andrew J. Pollard
 Anthony Brown
 Sarah L. Rowland-Jones
 Juthathip Mongkolsapaya
 Eleanor Barnes
 Susan Hopkins
 Victoria Hall
 Christina Dold
 Christopher J.A. Duncan
 Alex Richter
 Miles Carroll
 Gavin Screaton
 Thushan I. de Silva
 Lance Turtle
 Paul Klenerman
 Susanna Dunachie
 Hibatullah Abuelgasim
 Emily Adland
 Syed Adlou
 Hossain Delowar Akther
 Ahmed Alhussni
 Mohammad Ali
 M. Azim Ansari
 Carolina V. Arancibia-Cárcamo
 Martin Bayley
 Helen Brown
 Jeremy Chalk
 Meera Chand
 Anu Chawla
 Senthil Chinnakannan
 Jospeh Cutteridge
 Catherine de Lara
 Lucy Denly
 Ben Diffey
 Stavros Dimitriadis
 Thomas M. Drake
 Timothy Donnison
 Maeva Dupont
 David Eyre
 Alex Fairman
 Siobhan Gardiner
 Javier Gilbert-Jarmillo
 Philip Goulder
 Carl Philipp Hackstein
 Sophie Hambleton
 Muzlifah Haniffa
 Jenny Haworth
 Jennifer Holmes
 Emily Horner
 Anni Jämsén
 Chris Jones
 Mwila Kasanyinga
 Sinead Kelly
 Rosemary Kirk
 Michael L. Knight
 Allan Lawrie
 Lian Lee

Other Contributor(s)

Siriraj Hospital
 Mahidol Oxford Tropical Medicine Research Unit
 Oxford University Hospitals NHS Foundation Trust
 Liverpool University Hospitals NHS Foundation Trust
 Public Health England
 University of Oxford
 University Hospitals Birmingham NHS Foundation Trust
 Sheffield Teaching Hospitals NHS Foundation Trust
 University of Liverpool
 Imperial College Faculty of Medicine
 University of Birmingham
 Nuffield Department of Medicine
 Newcastle University
 University of Oxford Medical Sciences Division
 The University of Sheffield
 The Newcastle Upon Tyne Hospitals NHS Foundation Trust
 Great North Children's Hospital

Abstract

Extension of the interval between vaccine doses for the BNT162b2 mRNA vaccine was introduced in the United Kingdom to accelerate population coverage with a single dose. At this time, trial data were lacking, and we addressed this in a study of United Kingdom healthcare workers. The first vaccine dose induced protection from infection from the circulating alpha (B.1.1.7) variant over several weeks. In a substudy of 589 individuals, we show that this single dose induces severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing antibody (NAb) responses and a sustained B and T cell response to the spike protein. NAb levels were higher after the extended dosing interval (6–14 weeks) compared with the conventional 3- to 4-week regimen, accompanied by enrichment of CD4+ T cells expressing interleukin-2 (IL-2). Prior SARS-CoV-2 infection amplified and accelerated the response. These data on dynamic cellular and humoral responses indicate that extension of the dosing interval is an effective immunogenic protocol.

Keyword(s)

Biochemistry, Genetics and Molecular Biology

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/75958

Collections

Scopus 2021