Publication: The absence of antagonism between extracts of Clinacanthus nutans Burm. and Naja naja siamensis venom
Issued Date
1977-12-01
Resource Type
ISSN
00383619
Other identifier(s)
2-s2.0-0017698931
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.8, No.2 (1977), 249-254
Suggested Citation
C. Cherdchu, N. Poopyruchpong, R. Adchariyasucha, K. Ratanabanangkoon The absence of antagonism between extracts of Clinacanthus nutans Burm. and Naja naja siamensis venom. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.8, No.2 (1977), 249-254. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/10285
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
The absence of antagonism between extracts of Clinacanthus nutans Burm. and Naja naja siamensis venom
Other Contributor(s)
Abstract
Clinacanthus nutans Burm., a herb reputed in Thialand and Malaysia to be 'snakebite antidote' has been tested in vitro and in vivo for antivenin activity. The aqueous extract of C. nutans leaves has been found to have no effect on the inhibition of neuromuscular transmission produced by purified Naja naja siamensis neurotoxin in isolated rat phrenic nerve diaphragm preparations. The extract of C. nutans, when given orally or intraperitoneally, are ineffective in prolonging the survival time of experimental mice receiving lethal doses of N.n. siamensis crude venom. Oral administrations of the herb extracts pretreated with α-amylase or β-amylase also fail to protect the animals. It is concluded that the extract of C. nutans cannot antagonize the action of cobra venom.