Publication: Molecular docking studies and anti-snake venom metalloproteinase activity of thai mango seed kernel extract
Issued Date
2009-09-01
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ISSN
14203049
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2-s2.0-70349554799
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Mahidol University
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SCOPUS
Bibliographic Citation
Molecules. Vol.14, No.9 (2009), 3198-3213
Suggested Citation
Pimolpan Pithayanukul, Jiraporn Leanpolchareanchai, Patchreenart Saparpakorn Molecular docking studies and anti-snake venom metalloproteinase activity of thai mango seed kernel extract. Molecules. Vol.14, No.9 (2009), 3198-3213. doi:10.3390/molecules14093198 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/27148
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Title
Molecular docking studies and anti-snake venom metalloproteinase activity of thai mango seed kernel extract
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Abstract
Snakebite envenomations cause severe local tissue necrosis and the venom metalloproteinases are thought to be the key toxins involved. In this study, the ethanolic extract from seed kernels of Thai mango (Mangifera indica L. cv. 'Fahlun;) (Anacardiaceae) and its major phenolic principle (pentagalloylglucopyranose) exhibited potent and dose-dependent inhibitory effects on the caseinolytic and fibrinogenolytic activities of Malayan pit viper and Thai cobra venoms in in vitro tests. Molecular docking studies revealed that the binding orientations of the phenolic principles were in the binding pockets of snake venom metalloproteinases (SVMPs). The phenolic principles could form hydrogen bonds with the three histidine residues in the conserved zinc-binding motif and could chelate the Zn2+atom of the SVMPs, which could potentially result in inhibition of the venom enzymatic activities and thereby inhibit tissue necrosis. © 2009 by the authors.