Publication: Is prolactin the cardinal calciotropic maternal hormone?
Issued Date
2010-07-01
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ISSN
10432760
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2-s2.0-77954311523
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Mahidol University
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SCOPUS
Bibliographic Citation
Trends in Endocrinology and Metabolism. Vol.21, No.7 (2010), 395-401
Suggested Citation
Narattaphol Charoenphandhu, Kannikar Wongdee, Nateetip Krishnamra Is prolactin the cardinal calciotropic maternal hormone?. Trends in Endocrinology and Metabolism. Vol.21, No.7 (2010), 395-401. doi:10.1016/j.tem.2010.02.002 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/28673
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Title
Is prolactin the cardinal calciotropic maternal hormone?
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Abstract
To produce offspring, mothers require a large amount of calcium for fetal growth and milk production. Increased calcium demand leads to enhanced intestinal calcium absorption and stockpiling of bone calcium in pregnancy prior to demineralization in lactation. These coordinated events must be carefully organized by calciotropic hormone(s), but the classical hormones, namely 1,25-dihydroxyvitamin D3, parathyroid hormone and calcitonin, do not appear to be responsible. Plasma prolactin (PRL) levels are elevated during pregnancy and, in view of the presence of PRL receptors in gut, bone and mammary glands, as well as recent evidence of the stimulatory effects of PRL on intestinal calcium transport, bone resorption and mammary calcium secretion, we postulate that PRL is the cardinal calciotropic hormone during pregnancy and lactation. © 2010 Elsevier Ltd.