Publication:
Recurrent macrophage activation syndrome as the primary manifestation in systemic lupus erythematosus and the benefit of serial ferritin measurements: A case-based review

Issued Date

2013-06-01

Resource Type

Review

ISSN

14349949
07703198

DOI

10.1007/s10067-013-2227-1

Other identifier(s)

2-s2.0-84879243599

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Clinical Rheumatology. Vol.32, No.6 (2013), 899-904

Suggested Citation

Soamarat Vilaiyuk, Nongnuch Sirachainan, Suthep Wanitkun, Kwanchai Pirojsakul, Jarin Vaewpanich Recurrent macrophage activation syndrome as the primary manifestation in systemic lupus erythematosus and the benefit of serial ferritin measurements: A case-based review. Clinical Rheumatology. Vol.32, No.6 (2013), 899-904. doi:10.1007/s10067-013-2227-1 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/32304

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Title

Recurrent macrophage activation syndrome as the primary manifestation in systemic lupus erythematosus and the benefit of serial ferritin measurements: A case-based review

Author(s)

Soamarat Vilaiyuk
 Nongnuch Sirachainan
 Suthep Wanitkun
 Kwanchai Pirojsakul
 Jarin Vaewpanich

Other Contributor(s)

Mahidol University

Abstract

Macrophage activation syndrome (MAS) is a fatal complication in rheumatic diseases. It is characterized by prolonged fever, pancytopenia, and hepatosplenomegaly, which are consequences of uncontrolled macrophage activation. MAS in children is most commonly associated with systemic juvenile idiopathic arthritis. Its association with systemic lupus erythematosus (SLE) is relatively rare, so we report a Thai boy who initially presented with MAS and eventually was diagnosed as having SLE. He also had recurrent MAS during the course of therapy. Hyperferritinemia is one of the abnormal laboratory findings in MAS and it has been used as an inflammatory marker. However, its correlation with disease activity remains unclear. Therefore, a review of literature regarding MAS-associated SLE in children and ferritin level in this disease was carried out. © 2013 Clinical Rheumatology.

Keyword(s)

Medicine

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https://repository.li.mahidol.ac.th/handle/20.500.14594/32304

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