Dengue virus, the causative agent of dengue fever (DF) and more severe forms of the disease - dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS) - can infect a number of different types of cells. While monocytes and macrophages are considered to be primary target cells driving the pathology of the disease, numerous studies have implicated the liver as a site of dengue virus replication and both clinical observations and experimental data support a role of the liver in dengue disease. This review aims to provide a brief overview of the data supporting a role of the liver in the pathology of dengue disease.
