Publication: Influence of cellular lipid content on influenza A virus replication
Issued Date
2020-05-01
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ISSN
14328798
03048608
03048608
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2-s2.0-85082968534
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Mahidol University
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SCOPUS
Bibliographic Citation
Archives of Virology. Vol.165, No.5 (2020), 1151-1161
Suggested Citation
Nattavatchara Limsuwat, Chompunuch Boonarkart, Supinya Phakaratsakul, Ornpreya Suptawiwat, Prasert Auewarakul Influence of cellular lipid content on influenza A virus replication. Archives of Virology. Vol.165, No.5 (2020), 1151-1161. doi:10.1007/s00705-020-04596-5 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/54567
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Title
Influence of cellular lipid content on influenza A virus replication
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Abstract
© 2020, Springer-Verlag GmbH Austria, part of Springer Nature. Influenza A virus (IAV) depends on the metabolism of its cellular host to provide energy and essential factors, including lipids, for viral replication. Previous studies have shown that fatty acids (FAs) play an important role in IAV replication and that inhibition of FA biosynthesis can diminish viral replication. However, cellular lipids can either be synthesized intracellularly or be imported from the extracellular environment. Interfering with FA import mechanisms may reduce the cellular lipid content and inhibit IAV replication. To test this hypothesis, MDCK and Detroit 562 cells were infected with IAV followed by exposure to palmitic acid and inhibitors of FA import. Replication of IAV significantly increased when infected cells were supplied with palmitic acid. This enhancement could be reduced by adding an FA import inhibitor. The addition of palmitic acid significantly increased the cellular lipid content, and this increased level was reduced by treatment with an FA import inhibitor. These results show that reducing the cellular lipid level might be an approach for IAV therapy.