Publication: Preliminary study on safety and efficacy of a Thai herbal remedy in persistent allergic rhinitis: A Randomized Double-blind Placebo-controlled Trial
Issued Date
2019-01-01
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01252208
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2-s2.0-85074653941
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.102, No.8 (2019), 24-29
Suggested Citation
S. Tandhavadhana, W. Maek-A-Nantawat, B. Phonrat, C. Picheansoonthon, P. Pitisuttithum Preliminary study on safety and efficacy of a Thai herbal remedy in persistent allergic rhinitis: A Randomized Double-blind Placebo-controlled Trial. Journal of the Medical Association of Thailand. Vol.102, No.8 (2019), 24-29. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/52228
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Title
Preliminary study on safety and efficacy of a Thai herbal remedy in persistent allergic rhinitis: A Randomized Double-blind Placebo-controlled Trial
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Abstract
© JOURNAL OF THE MEDICAL ASSOCIATION OF THAILAND| 2019 Background: Globally, the prevalence of allergic rhinitis has increased significantly. However, herbal remedies for allergic rhinitis were recorded on Wat Pho’s marble inscription in 1832, yet have never been scientifically studied. Objective: To identify the safe and appropriate dose of an herbal remedy comprising six herbs in healthy adults, and to explore the safety and preliminary efficacy of the remedy. Materials and Methods: Phase I, a randomized, non-blinded study focusing on safety of the studied drug included 16 healthy participants. Phase IIa, a randomized, double-blind, placebo-controlled trial, included 44 patients with persistent allergic rhinitis. Results: Generally the Thai herbal remedy was safe. However, diarrhea was reported significantly move often in the group that received the remedy than in the placebo group (p = 0.029). The appropriate dose was determined to be two capsules (1.12 g) after meals, three times per day. Preliminary efficacy according to symptom-score evaluation by a physician revealed significant improvements in 3 symptoms. The more than 25% improvement in peak nasal inspiratory flow was detected in participants who received herbal remedy (p = 0.018). Conclusion: This herbal remedy was well tolerated, with a somewhat increased occurrence of diarrhea. Although the study showed some symptom improvement.