Publication: Short report: The role and significance of sputum cultures in the diagnosis of melioidosis
Issued Date
2005-10-01
Resource Type
ISSN
00029637
Other identifier(s)
2-s2.0-26844487028
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Mahidol University
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SCOPUS
Bibliographic Citation
American Journal of Tropical Medicine and Hygiene. Vol.73, No.4 (2005), 657-661
Suggested Citation
Diana Huis In't Veld, Vanaporn Wuthiekanun, Allen C. Cheng, Wirongrong Chierakul, Wipada Chaowagul, Annemarie E. Brouwer, Nicholas J. White, Nicholas P.J. Day, Sharon J. Peacock Short report: The role and significance of sputum cultures in the diagnosis of melioidosis. American Journal of Tropical Medicine and Hygiene. Vol.73, No.4 (2005), 657-661. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/16549
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Title
Short report: The role and significance of sputum cultures in the diagnosis of melioidosis
Abstract
Pneumonia is a common manifestation of melioidosis, the disease caused by Burkholderia pseudomallei. In this study, we defined the prognostic significance of a positive sputum culture. A total of 712 patients presenting to Sappasithiprasong Hospital, Ubon Ratchathani, Thailand, with melioidosis between January 1992 and December 2002 had a sputum culture performed during admission, which was positive for B. pseudomallei in 444 patients (62%). The median duration of sputum positivity was 9 days (range, 1 to 49 days). Sputum cultures were negative in 32% of patients with radiologic changes suggestive of pulmonary involvement. Overall in-hospital mortality was 48%. A positive sputum culture was associated with mortality (adjusted OR 2.8, 95% CI: 1.9, 4.0; P < 0.001). This was independent of renal disease, a prior history of melioidosis, positive blood cultures, and other potential confounders. The presence of B. pseudomallei in the sputum of patients with melioidosis is associated with a poorer prognosis. Copyright © 2005 by The American Society of Tropical Medicine and Hygiene.