αthaiassemia in Thailand

Abstract

The αthalassemia syndromes are remarkable both for their phenotypic diversity and for their different clinical severity. They are associated with variable degrees of αchain deficits; the clinical manifestations range from asymptomatic cases with normal hematologic findings to the totally lethal Hb Bart's hydrops fetalis syndrome. Recent molecular biology studies have clarified the defects in these αthalassemia syndromes around the world. This paper describes the αthalassemias in Thailand, and covers the types, molecular defects, incidence of each genotype, and their phenotypic expression. © 1988 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.