Publication:
Patient-based transcriptome-wide analysis identify interferon and ubiquination pathways as potential predictors of influenza a disease severity

Issued Date

2014-11-03

Resource Type

Article

ISSN

19326203

DOI

10.1371/journal.pone.0111640

Other identifier(s)

2-s2.0-84909594544

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

PLoS ONE. Vol.9, No.11 (2014)

Suggested Citation

Long Truong Hoang, Thomas Tolfvenstam, Eng Eong Ooi, Chiea Chuen Khor, Ahmand Nazri, Mohamed Naim, Eliza Xin Pei Ho, Swee Hoe Ong, Heiman F. Wertheim, Annette Fox, Chau Van Vinh Nguyen, Ngoc My Nghiem, Tuan Manh Ha, Anh Thi Ngoc Tran, Paul Tambayah, Raymond Lin, Chariya Sangsajja, Weerawat Manosuthi, Chareon Chuchottaworn, Piamlarp Sansayunh, Tawee Chotpitayasunondh, Piyarat Suntarattiwong, Kulkanya Chokephaibulkit, Pilaipan Puthavathana, Menno D. De Jong, Jeremy Farrar, H. Rogier Van Doorn, Martin Lloyd Hibberd Patient-based transcriptome-wide analysis identify interferon and ubiquination pathways as potential predictors of influenza a disease severity. PLoS ONE. Vol.9, No.11 (2014). doi:10.1371/journal.pone.0111640 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/32968

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Title

Patient-based transcriptome-wide analysis identify interferon and ubiquination pathways as potential predictors of influenza a disease severity

Author(s)

Long Truong Hoang
 Thomas Tolfvenstam
 Eng Eong Ooi
 Chiea Chuen Khor
 Ahmand Nazri
 Mohamed Naim
 Eliza Xin Pei Ho
 Swee Hoe Ong
 Heiman F. Wertheim
 Annette Fox
 Chau Van Vinh Nguyen
 Ngoc My Nghiem
 Tuan Manh Ha
 Anh Thi Ngoc Tran
 Paul Tambayah
 Raymond Lin
 Chariya Sangsajja
 Weerawat Manosuthi
 Chareon Chuchottaworn
 Piamlarp Sansayunh
 Tawee Chotpitayasunondh
 Piyarat Suntarattiwong
 Kulkanya Chokephaibulkit
 Pilaipan Puthavathana
 Menno D. De Jong
 Jeremy Farrar
 H. Rogier Van Doorn
 Martin Lloyd Hibberd

Other Contributor(s)

Genome Institute of Singapore
 UCL
 Nuffield Department of Clinical Medicine
 Academic Medical Centre, University of Amsterdam
 Oxford University Clinical Research Unit
 Children's Hospital 2
 National University Hospital, Singapore
 Bamrasnaradura Infectious Disease Institute
 Chest Disease Institute
 Queen Sirikit National Institute of Child Health
 Mahidol University
 Karolinska Institutet

Abstract

Background: The influenza A virus is an RNA virus that is responsible for seasonal epidemics worldwide with up to five million cases of severe illness and 500, 000 deaths annually according to the World Health Organization estimates. The factors associated with severe diseases are not well defined, but more severe disease is more often seen among persons aged ≥ 65 years, infants, pregnant women, and individuals of any age with underlying health conditions.Methodology/Principal Findings: Using gene expression microarrays, the transcriptomic profiles of influenza-infected patients with severe (N = 11), moderate (N = 40) and mild (N = 83) symptoms were compared with the febrile patients of unknown etiology (N = 73). We found that influenza-infected patients, regardless of their clinical outcomes, had a stronger induction of antiviral and cytokine responses and a stronger attenuation of NK and T cell responses in comparison with those with unknown etiology. More importantly, we found that both interferon and ubiquitination signaling were strongly attenuated in patients with the most severe outcomes in comparison with those with moderate and mild outcomes, suggesting the protective roles of these pathways in disease pathogenesis.Conclusion/Significances: The attenuation of interferon and ubiquitination pathways may associate with the clinical outcomes of influenza patients.

Keyword(s)

Agricultural and Biological Sciences
 Biochemistry, Genetics and Molecular Biology

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/32968

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