Publication: Performance and cost analysis of Siriraj liquid-based cytology: A direct-to-vial study
Issued Date
2009-12-01
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03012115
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2-s2.0-71849107275
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Mahidol University
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SCOPUS
Bibliographic Citation
European Journal of Obstetrics Gynecology and Reproductive Biology. Vol.147, No.2 (2009), 201-205
Suggested Citation
Somsak Laiwejpithaya, Mongkol Benjapibal, Sujera Laiwejpithaya, Weerasak Wongtiraporn, Suthi Sangkarat, Manee Rattanachaiyanont Performance and cost analysis of Siriraj liquid-based cytology: A direct-to-vial study. European Journal of Obstetrics Gynecology and Reproductive Biology. Vol.147, No.2 (2009), 201-205. doi:10.1016/j.ejogrb.2009.08.002 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/27839
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Title
Performance and cost analysis of Siriraj liquid-based cytology: A direct-to-vial study
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Abstract
Objective: To compare the cytological diagnoses, specimen adequacy, and cost of the Siriraj liquid-based cytology (LBC) with those of the conventional smear technique. Study design: An observational study with historical comparison was conducted in a tertiary university hospital. Cytological reports of 23,676 Siriraj-LBC specimens obtained in 2006 were compared with those of 25,510 conventional smears obtained in 2004. Results: Overall prevalence of abnormal cervical cytology detected by conventional smear was 1.76% and by Siriraj-LBC was 3.70%. Compared with the conventional method, the Siriraj-LBC yielded a significantly higher overall detection rate of abnormal cervical cytology, with a 110.23% increase in the detection rate (P < 0.001), mainly due to the increase in diagnosis of squamous intraepithelial lesions (SIL), both low and high grade, together with atypical squamous cells of undetermined significance, "atypical squamous cells cannot exclude HSIL", and malignancies, but not atypical glandular cells. The Siriraj-LBC had a smaller proportion of unsatisfactory slides (4.94% vs. 18.60%, P < 0.001) and a higher negative predictive value (96.33% vs. 92.74%, P = 0.001), but no difference in positive predictive value (83.03% vs. 86.83%, P = 0.285). The cost of Siriraj-LBC was approximately 67% higher than that of the conventional cytology used in Siriraj Hospital and 50-70% lower than that of the commercially available LBC techniques in Thailand. Conclusion: The Siriraj-LBC increases the detection rate of abnormal cytology, improves specimen adequacy, and enhances the negative predictive value without compromising the positive predictive value. For centers where conventional Pap smear does not perform well, the introduction of a low cost Siriraj-LBC might help to improve performance and it may be an economical alternative to the commercially available liquid-based cytology. © 2009 Elsevier Ireland Ltd. All rights reserved.