Publication: Orientia tsutsugamushi, agent of scrub typhus, displays a single metapopulation with maintenance of ancestral haplotypes throughout continental South East Asia
Issued Date
2015-04-01
Resource Type
ISSN
15677257
15671348
15671348
Other identifier(s)
2-s2.0-84921408099
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Mahidol University
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SCOPUS
Bibliographic Citation
Infection, Genetics and Evolution. Vol.31, (2015), 1-8
Suggested Citation
Patimaporn Wongprompitak, Veasna Duong, Wichittra Anukool, Lay Sreyrath, Trinh Thi Xuan Mai, Laurent Gavotte, Catherine Moulia, Emmanuel Cornillot, Pattama Ekpo, Yupin Suputtamongkol, Philippe Buchy, Roger Frutos Orientia tsutsugamushi, agent of scrub typhus, displays a single metapopulation with maintenance of ancestral haplotypes throughout continental South East Asia. Infection, Genetics and Evolution. Vol.31, (2015), 1-8. doi:10.1016/j.meegid.2015.01.005 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/35180
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Title
Orientia tsutsugamushi, agent of scrub typhus, displays a single metapopulation with maintenance of ancestral haplotypes throughout continental South East Asia
Abstract
© 2015 Elsevier B.V. Orientia tsutsugamushi is the causative agent of scrub typhus, a major cause of febrile illness in rural area of Asia-Pacific region. A multi-locus sequence typing (MLST) analysis was performed on strains isolated from human patients from 3 countries in Southeast Asia: Cambodia, Vietnam and Thailand. The phylogeny of the 56-kDa protein encoding gene was analyzed on the same strains and showed a structured topology with genetically distinct clusters. MLST analysis did not lead to the same conclusion. DNA polymorphism and phylogeny of individual gene loci indicated a significant level of recombination and genetic diversity whereas the ST distribution indicated the presence of isolated patches. No correlation was found with the geographic origin. This work suggests that weak divergence in core genome and ancestral haplotypes are maintained by permanent recombination in mites while the 56-kDa protein gene is diverging in higher speed due to selection by the mammalian immune system.