Publication: Melatonin regulates aging and neurodegeneration through energy metabolism, epigenetics, autophagy and circadian rhythm pathways.
Accepted Date
2014-09-12
Issued Date
2014
Resource Type
Language
eng
ISSN
1422-0067
Rights
Mahidol University
Bibliographic Citation
International Journal of Molecular Sciences. Vol.15, No.9 (2014), 16848-16884
Suggested Citation
Anorut Jenwitheesuk, Chutikorn Nopparat, Sujira Mukda, Prapimpun Wongchitrat, Piyarat Govitrapong Melatonin regulates aging and neurodegeneration through energy metabolism, epigenetics, autophagy and circadian rhythm pathways.. International Journal of Molecular Sciences. Vol.15, No.9 (2014), 16848-16884. doi:10.3390/ijms150916848 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/1851
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Title
Melatonin regulates aging and neurodegeneration through energy metabolism, epigenetics, autophagy and circadian rhythm pathways.
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Abstract
Brain aging is linked to certain types of neurodegenerative diseases and
identifying new therapeutic targets has become critical. Melatonin, a pineal hormone,
associates with molecules and signaling pathways that sense and influence energy
metabolism, autophagy, and circadian rhythms, including insulin-like growth factor 1
(IGF-1), Forkhead box O (FoxOs), sirtuins and mammalian target of rapamycin (mTOR)
signaling pathways. This review summarizes the current understanding of how melatonin,
together with molecular, cellular and systemic energy metabolisms, regulates epigenetic
processes in the neurons. This information will lead to a greater understanding of
molecular epigenetic aging of the brain and anti-aging mechanisms to increase lifespan
under healthy conditions.