Publication: Epidemiology of parvovirus B19 and anemia among kidney transplant recipients: A meta-analysis
Issued Date
2020-07-01
Resource Type
ISSN
09747834
09747796
09747796
Other identifier(s)
2-s2.0-85089123039
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Mahidol University
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SCOPUS
Bibliographic Citation
Urology Annals. Vol.12, No.3 (2020), 241-247
Suggested Citation
Charat Thongprayoon, Nadeen J. Khoury, Tarun Bathini, Narothama Reddy Aeddula, Boonphiphop Boonpheng, Ploypin Lertjitbanjong, Kanramon Watthanasuntorn, Napat Leeaphorn, Supavit Chesdachai, Aldo Torres-Ortiz, Wisit Kaewput, Jackrapong Bruminhent, Michael A. Mao, Wisit Cheungpasitporn Epidemiology of parvovirus B19 and anemia among kidney transplant recipients: A meta-analysis. Urology Annals. Vol.12, No.3 (2020), 241-247. doi:10.4103/UA.UA_89_19 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/58110
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Title
Epidemiology of parvovirus B19 and anemia among kidney transplant recipients: A meta-analysis
Other Contributor(s)
University of Minnesota Twin Cities
UMKC School of Medicine
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Mahidol University
The University of Arizona
Indiana University School of Medicine-Evansville
Henry Ford Hospital
Mayo Clinic
University of Mississippi Medical Center
The Mary Imogene Bassett Hospital
Mayo Clinic in Jacksonville, Florida
East Tennessee State University
UMKC School of Medicine
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Mahidol University
The University of Arizona
Indiana University School of Medicine-Evansville
Henry Ford Hospital
Mayo Clinic
University of Mississippi Medical Center
The Mary Imogene Bassett Hospital
Mayo Clinic in Jacksonville, Florida
East Tennessee State University
Abstract
© 2020 Urology Annals | Published by Wolters Kluwer-Medknow. Background: Persistent anemia has been described in kidney transplant (KTx) recipients with parvovirus B19 virus infection. However, the epidemiology of parvovirus B19 and parvovirus B19-related anemia after KTx remains unclear. We conducted this systematic review (1) to investigate the incidence of parvovirus B19 infection after KTx and (2) to assess the incidence of parvovirus B19 among KTx patients with anemia. Materials and Methods: A systematic review was conducted in EMBASE, MEDLINE, and Cochrane databases from inception to March 2019 to identify studies that reported the incidence rate of parvovirus B19 infection and/or seroprevalence of parvovirus B19 in KTx recipients. Effect estimates from the individual studies were extracted and combined using random-effects, generic inverse variance method of DerSimonian and Laird. The protocol for this systematic review is registered with PROSPERO (no. CRD42019125716). Results: Nineteen observational studies with a total of 2108 KTx patients were enrolled. Overall, the pooled estimated seroprevalence of parvovirus B19 immunoglobulin G was 62.2% (95% confidence interval [CI]: 45.8%-76.1%). The pooled estimated incidence rate of positive parvovirus B19 DNA in the 1st year after KTx was 10.3% (95% CI: 5.5%-18.4%). After sensitivity analysis excluded a study that solely included KTx patients with anemia, the pooled estimated incidence rate of positive parvovirus B19 DNA after KTx was 7.6% (95% CI: 3.7%-15.0%). Among KTx with anemia, the pooled estimated incidence rate of positive parvovirus B19 DNA was 27.4% (95% CI: 16.6%-41.7%). Meta-regression analysis demonstrated no significant correlations between the year of study and the incidence rate of positive parvovirus B19 DNA (P = 0.33). Egger's regression asymmetry test was performed and demonstrated no publication bias in all analyses. Conclusion: The overall estimated incidence of positive parvovirus B19 DNA after KTX is 10.3%. Among KTx with anemia, the incidence rate of positive parvovirus B19 DNA is 27.4%. The incidence of positive parvovirus B19 DNA does not seem to decrease overtime.