Publication:
Validation of the D: A: D Chronic Kidney Disease Risk Score Model Among People Living With HIV in the Asia-Pacific

Issued Date

2020-12-01

Resource Type

Article

ISSN

19447884

DOI

10.1097/QAI.0000000000002464

Other identifier(s)

2-s2.0-85095399729

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Mahidol University

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SCOPUS

Bibliographic Citation

Journal of acquired immune deficiency syndromes (1999). Vol.85, No.4 (2020), 489-497

Suggested Citation

Win Min Han, Rimke Bijker, Ezhilarasi Chandrasekaran, Sanjay Pujari, Oon Tek Ng, Penh Sun Ly, Man Po Lee, Kinh Van Nguyen, Yu Jiun Chan, Cuong Duy Do, Jun Yong Choi, Romanee Chaiwarith, Tuti Parwati Merati, Sasisopin Kiertiburanakul, Iskandar Azwa, Suwimon Khusuwan, Fujie Zhang, Yasmin Mohamed Gani, Junko Tanuma, Shashikala Sangle, Rossana Ditangco, Evy Yunihastuti, Jeremy Ross, Anchalee Avihingsanon Validation of the D: A: D Chronic Kidney Disease Risk Score Model Among People Living With HIV in the Asia-Pacific. Journal of acquired immune deficiency syndromes (1999). Vol.85, No.4 (2020), 489-497. doi:10.1097/QAI.0000000000002464 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/60025

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Title

Validation of the D: A: D Chronic Kidney Disease Risk Score Model Among People Living With HIV in the Asia-Pacific

Author(s)

Win Min Han
 Rimke Bijker
 Ezhilarasi Chandrasekaran
 Sanjay Pujari
 Oon Tek Ng
 Penh Sun Ly
 Man Po Lee
 Kinh Van Nguyen
 Yu Jiun Chan
 Cuong Duy Do
 Jun Yong Choi
 Romanee Chaiwarith
 Tuti Parwati Merati
 Sasisopin Kiertiburanakul
 Iskandar Azwa
 Suwimon Khusuwan
 Fujie Zhang
 Yasmin Mohamed Gani
 Junko Tanuma
 Shashikala Sangle
 Rossana Ditangco
 Evy Yunihastuti
 Jeremy Ross
 Anchalee Avihingsanon

Other Contributor(s)

Hospital Sungai Buloh
 Beijing Ditan Hospital Capital Medical University
 VHS Medical Centre India
 Gokila
 Bach Mai Hospital
 Universitas Udayana
 University of Indonesia, RSUPN Dr. Cipto Mangunkusumo
 Chulalongkorn University
 Kirby Institute
 National Center for Global Health and Medicine
 The HIV Netherlands Australia Thailand Research Collaboration
 Yonsei University College of Medicine
 Faculty of Medicine, Ramathibodi Hospital, Mahidol University
 Queen Elizabeth Hospital Hong Kong
 University of Malaya Medical Centre
 Veterans General Hospital-Taipei
 Tan Tock Seng Hospital
 BJ Government Medical College and Sassoon General Hospitals
 National Hospital for Tropical Diseases
 amfAR - The Foundation for AIDS Research
 Research Institute for Health Sciences
 Institute of Infectious Diseases
 Chiangrai Prachanukroh Hospital
 National Center for HIV/AIDS

Abstract

BACKGROUND: We validated the Data collection on Adverse events of anti-HIV Drugs (D:A:D) full-risk and short-risk score models for chronic kidney disease (CKD) in the Asian HIV cohorts. SETTINGS: A validation study among people living with HIV (PLHIV) aged ≥18 years among the cohorts in the Asia-Pacific region. METHODS: PLHIV with a baseline estimated glomerular filtration rate > 60 mL/min/1.73 m were included for validation of the D:A:D CKD full version and short version without cardiovascular risk factors. Those with <3 estimated glomerular filtration rate measurements from baseline or previous exposure to potentially nephrotoxic antiretrovirals were excluded. Kaplan-Meier methods were used to estimate the probability of CKD development. The area under the receiver operating characteristics was also used to validate the risk score. RESULTS: We included 5701 participants in full model {median 8.1 [interquartile range (IQR) 4.8-10.9] years follow-up} and 9791 in short model validation [median 4.9 (IQR 2.5-7.3) years follow-up]. The crude incidence rate of CKD was 8.1 [95% confidence interval (CI): 7.3 to 8.9] per 1000 person-years in the full model cohort and 10.5 (95% CI: 9.6 to 11.4) per 1000 person-years in the short model cohort. The progression rates for CKD at 10 years in the full model cohort were 2.7%, 8.9%, and 26.1% for low-risk, medium-risk, and high-risk groups, and 3.5%, 11.7%, and 32.4% in the short model cohort. The area under the receiver operating characteristics for the full-risk and short-risk score was 0.81 (95% CI: 0.79 to 0.83) and 0.83 (95% CI: 0.81 to 0.85), respectively. CONCLUSION: The D:A:D CKD full-risk and short-risk score performed well in predicting CKD events among Asian PLHIV. These risk prediction models may be useful to assist clinicians in identifying individuals at high risk of developing CKD.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/60025

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Scopus 2020