Publication: Antifertility effects of sulfapyridine on male hamsters
Issued Date
1991-01-01
Resource Type
ISSN
14390272
03034569
03034569
Other identifier(s)
2-s2.0-0025986201
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Mahidol University
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SCOPUS
Bibliographic Citation
Andrologia. Vol.23, No.4 (1991), 269-271
Suggested Citation
R. Weissenberg, C. Pholpramool, L. M. Lewin Antifertility effects of sulfapyridine on male hamsters. Andrologia. Vol.23, No.4 (1991), 269-271. doi:10.1111/j.1439-0272.1991.tb02557.x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/22009
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Title
Antifertility effects of sulfapyridine on male hamsters
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Abstract
Summary. Sulfapyridine was administered to mature male golden hamsters either by impregnation in feed pellets, or by subcutaneous injection as a solution in dimethylsulfoxide. The average litter size for control males was 8.3 ± 3.3 (n = 13) vs. 4.2 ± 2.7 (n = 11) for sulfapyridine‐fed treated animals. Histology of the testis and epididymis was normal and sperm were normal in morphology and motility. Subcutaneous injection of sulfapyridine caused much more dramatic inhibition of male fertility than was achieved by feeding the drug. Sulfapyridine (750 mg/kg body weight in 0.2 ml DMSO) injected subcutaneously for 60 days was effective in reducing testis size and sperm quality. Histology of testes showed spermatogenic arrest at young spermatids. Two classes of animals were found in both sulfapyridine‐fed and ‐injected treatment groups. One class was relatively resistant to the antifertility effects of the drugs. This difference may reflect differing abilities of the animals to convert sulfapyridine to an active form or to excrete its metabolites. 1991 Blackwell Verlag GmbH