Publication: The hemoglobin E thalassemias
Issued Date
2012-01-01
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ISSN
21571422
Other identifier(s)
2-s2.0-84886690091
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Mahidol University
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SCOPUS
Bibliographic Citation
Cold Spring Harbor Perspectives in Medicine. Vol.2, No.8 (2012)
Suggested Citation
Suthat Fucharoen, David J. Weatherall The hemoglobin E thalassemias. Cold Spring Harbor Perspectives in Medicine. Vol.2, No.8 (2012). doi:10.1101/cshperspect.a011734 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/13856
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Title
The hemoglobin E thalassemias
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Abstract
Hemoglobin E (HbE) is an extremely common structural hemoglobin variant that occurs at high frequencies throughout many Asian countries. It is a β-hemoglobin variant, which is produced at a slightly reduced rate and hence has the phenotype of a mild form of β thalassemia. Its interactions with different forms of α thalassemia result in a wide variety of clinical disorders, whereas its coinheritance with β thalassemia, a condition called hemoglobin E β thalassemia, is by far the most common severe form of β thalassemia in Asia and, globally, comprises approximately 50% of the clinically severe β-thalassemia disorders. © 2012 Cold Spring Harbor Laboratory Press all rights reserved.