Publication: MECHANISMS OF DEFECTIVE DELAYED CUTANEOUS HYPERSENSITIVITY IN CHILDREN WITH PROTEIN-CALORIE MALNUTRITION
Issued Date
1973-03-10
Resource Type
ISSN
01406736
Other identifier(s)
2-s2.0-0015919372
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
The Lancet. Vol.301, No.7802 (1973), 506-509
Suggested Citation
Robert Edelman, Robert Suskind, Robert E. Olson, Stitaya Sirisinha MECHANISMS OF DEFECTIVE DELAYED CUTANEOUS HYPERSENSITIVITY IN CHILDREN WITH PROTEIN-CALORIE MALNUTRITION. The Lancet. Vol.301, No.7802 (1973), 506-509. doi:10.1016/S0140-6736(73)90326-7 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/10194
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
MECHANISMS OF DEFECTIVE DELAYED CUTANEOUS HYPERSENSITIVITY IN CHILDREN WITH PROTEIN-CALORIE MALNUTRITION
Abstract
The three principal components of the delayed cutaneous-hypersensitivity response in children with protein-calorie malnutrition (P.C.M.) were evaluated with the contact allergen and skin irritant dinitrofluorobenzene (D.N.F.B.) and with Candida albicans skin-test antigen. D.N.F.B. indicated that 60-80% of P.C.M. patients on admission had malfunction of both their afferent limb and their cutaneous inflammatory response. Two patients with intact inflammatory responses to D.N.F.B. on admission, but with negative candida skin tests, later displayed positive candida skin tests, suggesting that the efferent limb was defective on admission. Except for these two patients, the impaired inflammatory reaction precluded independent evaluation of the efferent limb in vivo. The components of the delayed cutaneous-hypersensitivity reaction were intact in most patients after nutritional recovery, 1-2 months later. © 1973.