Publication: Estrogen Deficiency Leads to Further Bone Loss in the Mandible of CKD Mice.
Issued Date
2016-02-17
Resource Type
Language
eng
ISSN
1932-6203 (electronic)
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Mahidol University
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PLOS ONE
Bibliographic Citation
Guo Y, Sun N, Duan X, Xu X, Zheng L, Seriwatanachai D, Wang Y, Yuan Q.Estrogen Deficiency Leads to Further Bone Loss in the Mandible of CKD Mice. PLoS One. 2016 Feb 17;11(2):e0148804.
Suggested Citation
Dutmanee Seriwatanachai, ดุษมณี เสรีวัฒนาชัย, Guo, Yuchen, Sun, Ningyuan, Duan, Xiaobo, Xu, Xin, Zheng, Liwei, Wang, Yongyue, Yuan, Quan Estrogen Deficiency Leads to Further Bone Loss in the Mandible of CKD Mice.. Guo Y, Sun N, Duan X, Xu X, Zheng L, Seriwatanachai D, Wang Y, Yuan Q.Estrogen Deficiency Leads to Further Bone Loss in the Mandible of CKD Mice. PLoS One. 2016 Feb 17;11(2):e0148804.. doi:10.1371/journal.pone.0148804. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/934
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Title
Estrogen Deficiency Leads to Further Bone Loss in the Mandible of CKD Mice.
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Abstract
BACKGROUND:
Chronic kidney disease (CKD) has been regarded as a grave public health problem. Estrogen is a critical factor for both renal protection and bone remodeling. Our previous study demonstrated that CKD impairs the healing of titanium implants. The aim of this study was to investigate the effects of estrogen deficiency on the mandibular bone in CKD mice.
METHODS:
Forty eleven-week-old female C57BL mice were used in this study. Uremia and estrogen deficiency were induced by 5/6 nephrectomy and ovariectomy (OVX), respectively. After 8 weeks, the mice were sacrificed, and their mandibles were collected for micro-CT analysis and histological examination.
RESULTS:
All the mice survived the experimental period. Serum measurements confirmed a significant increase in BUN in the CKD group that was further increased by OVX. OVX led to significant decreases in both the BV/TV and cortical thickness of the mandibular bone in CKD mice.
CONCLUSION:
In summary, our findings indicate that estrogen deficiency leads to further mandibular bone loss in CKD mice.