Publication: Peripapillary Perfused Capillary Density in Acute Angle-Closure Glaucoma: An Optical Coherence Tomography Angiography Study
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Issued Date
2021-01-19
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21620989
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2-s2.0-85103800321
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Mahidol University
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SCOPUS
Bibliographic Citation
Asia-Pacific journal of ophthalmology (Philadelphia, Pa.). Vol.10, No.2 (2021), 167-172
Suggested Citation
Yanin Suwan, Masoud Aghsaei Fard, Purit Petpiroon, Wasu Supakontanasan, Rotjaporn Pruksacholavit, Apichat Tantraworasin, Chaiwat Teekhasaenee, Robert Ritch Peripapillary Perfused Capillary Density in Acute Angle-Closure Glaucoma: An Optical Coherence Tomography Angiography Study. Asia-Pacific journal of ophthalmology (Philadelphia, Pa.). Vol.10, No.2 (2021), 167-172. doi:10.1097/APO.0000000000000370 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/78507
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Title
Peripapillary Perfused Capillary Density in Acute Angle-Closure Glaucoma: An Optical Coherence Tomography Angiography Study
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Abstract
PURPOSE: To compare peripapillary perfused capillary density (PCD) on optical coherence tomography angiography among resolved acute angle-closure (AAC), primary open-angle glaucoma (POAG), and control eyes. DESIGN: Prospective, cross-sectional, observational study. METHODS: All patients with resolved AAC or POAG of varying severity and controls were enrolled. We obtained 4.5 × 4.5 mm2 optical coherence tomography angiography images of the optic nerve head. PCD was analyzed using customized software with major vessel removal. Continuous variables were assessed using the analysis of variance and Bonferroni correction test. A marginal model of generalized estimating equations was used to adjust for confounding factors and interocular correlation. RESULTS: The study included 44 eyes with resolved AAC (mean duration of elevated intraocular pressure, 8.1 ± 10.9 days), 69 eyes with POAG, and 49 control eyes. PCD showed a similar decrease between AAC and POAG eyes (P > 0.99). After adjusting for age and sex, the mean difference in global PCD between each of the POAG stage groups and the AAC group was the highest in the severe POAG group (-3.43; 95% confidence interval [CI], -11.38 to 2.52; P = 0.211), followed by the mild POAG (0.68; 95% CI, -3.26 to 4.62; P = 0.735) and moderate POAG (0.20; 95% CI, -5.21 to 5.61; P = 0.942) groups. The duration of increased intraocular pressure did not affect PCD (P = 0.258 and 0.168 for global and annular PCDs, respectively). CONCLUSIONS: The degree of microvascular attenuation in AAC eyes was not different from that in POAG eyes.