Publication: Decreased hemoglobin concentrations, hyperparasitemia, and severe malaria are associated with increased Plasmodium falciparum gametocyte carriage
Issued Date
2002-01-01
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ISSN
00223395
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2-s2.0-0036200466
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Parasitology. Vol.88, No.1 (2002), 97-101
Suggested Citation
Mathieu Nacher, Pratap Singhasivanon, Udomsak Silachamroon, Sombat Treeprasertsuk, Thanawat Tosukhowong, Suparp Vannaphan, Frédérick Gay, Dominique Mazier, Sornchai Looareesuwan Decreased hemoglobin concentrations, hyperparasitemia, and severe malaria are associated with increased Plasmodium falciparum gametocyte carriage. Journal of Parasitology. Vol.88, No.1 (2002), 97-101. doi:10.1645/0022-3395(2002)088[0097:DHCHAS]2.0.CO;2 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20004
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Title
Decreased hemoglobin concentrations, hyperparasitemia, and severe malaria are associated with increased Plasmodium falciparum gametocyte carriage
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Abstract
To determine factors influencing gametocyte carriage, a cross-sectional study was conducted among 512 patients admitted for Plasmodium falciparum malaria. After adjustments for potential confounders, hemoglobin concentrations were lower in gametocyte carriers 10.5 (±2.5) than in patients without gametocytes 12.5 (±2.3) (P <: 0.0001). Hemoglobin concentrations were negatively correlated with peak gametocyte counts (Spearman's p = -0.37, P < 0.0001) and gametocyte carriage durations (Spearman's p = -0.30, P < 0.0001). Adjustments for the duration of the malaria episode and other potential confounders did not alter the association (P < 0.0001). After adjustment for potential confounders, the median asexual parasitemia was higher in patients with gametocytes than in patients without gametocytes (P = 0.003). Severe malaria cases were more likely to have gametocytes (65%) than malaria with hyperparasitemia (38%) or mild malaria (31%) (P = 0.0001). These findings suggest that events surrounding anemia and tissue hypoxia stimulate Plasmodium falciparum gametocytogenesis.