Publication: Genetic analysis of dog rabies viruses circulating in Bangkok
Issued Date
2006-05-01
Resource Type
ISSN
15671348
Other identifier(s)
2-s2.0-33645560711
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Mahidol University
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SCOPUS
Bibliographic Citation
Infection, Genetics and Evolution. Vol.6, No.3 (2006), 235-240
Suggested Citation
Pakamatz Khawplod, Yoko Shoji, Sukathida Ubol, Channarong Mitmoonpitak, Henry Wilde, Akira Nishizono, Ichiro Kurane, Kinjiro Morimoto Genetic analysis of dog rabies viruses circulating in Bangkok. Infection, Genetics and Evolution. Vol.6, No.3 (2006), 235-240. doi:10.1016/j.meegid.2005.06.002 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/22902
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Title
Genetic analysis of dog rabies viruses circulating in Bangkok
Abstract
The genetic diversity of the rabies virus glycoprotein (G) gene isolated from individual rabid dogs (inter-hosts) and within a single infected dog (intra-host) has been analyzed in an effort to better understand selective pressures and population shifts among rabies viruses circulating in Bangkok. Comparison of individual master sequences among inter-hosts revealed that the dog virus isolates circulating in Bangkok were phylogenetically closely related. The ectodomain of the glycoprotein was highly conserved among the virus isolates. Furthermore, the genetic diversity of the G gene within an intra-host was assessed by comparing the cloned sequences in the virus population. The comparisons revealed that rabies virus circulating in an intra-host consisted of closely related heterogenous populations with minor substitutions at nucleotide (0.19%) and amino acid levels. © 2005 Elsevier B.V. All rights reserved.