Publication:
Limited polymorphism in the dihydropteroate synthetase gene (dhps) of Plasmodium vivax isolates from Thailand

Issued Date

2005-10-01

Resource Type

Article

ISSN

00664804

DOI

10.1128/AAC.49.10.4393-4395.2005

Other identifier(s)

2-s2.0-25844506182

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Antimicrobial Agents and Chemotherapy. Vol.49, No.10 (2005), 4393-4395

Suggested Citation

Mallika Imwong, Sasithon Pukrittayakamee, Qin Cheng, Catrin Moore, Sornchai Looareesuwan, Georges Snounou, Nicholas J. White, Nicholas P.J. Day Limited polymorphism in the dihydropteroate synthetase gene (dhps) of Plasmodium vivax isolates from Thailand. Antimicrobial Agents and Chemotherapy. Vol.49, No.10 (2005), 4393-4395. doi:10.1128/AAC.49.10.4393-4395.2005 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/16815

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Title

Limited polymorphism in the dihydropteroate synthetase gene (dhps) of Plasmodium vivax isolates from Thailand

Author(s)

Mallika Imwong
 Sasithon Pukrittayakamee
 Qin Cheng
 Catrin Moore
 Sornchai Looareesuwan
 Georges Snounou
 Nicholas J. White
 Nicholas P.J. Day

Other Contributor(s)

Mahidol University
 Australian Army Malaria Institute
 Churchill Hospital
 Institut Pasteur, Paris

Abstract

The dhps sequences of 55 Plasmodium vivax isolates (39 from Thailand and 16 from elsewhere) revealed mutant Pvdhps at codons 383 and/or 553 (A → G) in 33 isolates, all from Thailand. Mutations of P\dhps and P\dhfr were correlated. Multiple mutations were associated with high-grade sulfadoxine-pyrimethamine resistance. Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Keyword(s)

Medicine
 Pharmacology, Toxicology and Pharmaceutics

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/16815

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Scopus 2001-2005