Publication:
Azide-Triggered Bicyclization of o-Alkynylisocyanobenzenes: Synthesis of Tetrazolo[1,5-a]quinolines

Issued Date

2019-11-14

Resource Type

Article

ISSN

10990690
1434193X

DOI

10.1002/ejoc.201901209

Other identifier(s)

2-s2.0-85074416371

Rights

Mahidol University

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SCOPUS

Bibliographic Citation

European Journal of Organic Chemistry. Vol.2019, No.42 (2019), 7050-7057

Suggested Citation

Onnicha Khaikate, Darunee Soorukram, Pawaret Leowanawat, Manat Pohmakotr, Vichai Reutrakul, Chutima Kuhakarn Azide-Triggered Bicyclization of o-Alkynylisocyanobenzenes: Synthesis of Tetrazolo[1,5-a]quinolines. European Journal of Organic Chemistry. Vol.2019, No.42 (2019), 7050-7057. doi:10.1002/ejoc.201901209 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/50547

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Title

Azide-Triggered Bicyclization of o-Alkynylisocyanobenzenes: Synthesis of Tetrazolo[1,5-a]quinolines

Author(s)

Onnicha Khaikate
 Darunee Soorukram
 Pawaret Leowanawat
 Manat Pohmakotr
 Vichai Reutrakul
 Chutima Kuhakarn

Other Contributor(s)

Mahidol University

Abstract

© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim An efficient and rapid synthetic approach for the synthesis of tetrazolo[1,5-a]quinolines has been developed employing the reaction of o-alkynylisocyanobenzenes with sodium azide. The present strategy involved nucleophilic addition of azide to isocyanide followed by 6-endo cyclization. The reaction gives access to a collection of tetrazolo[1,5-a]quinolines with broad functional group in moderate to high yields under metal-, and base-free conditions.

Keyword(s)

Chemistry

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/50547

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Scopus 2019