Publication: Relationship of vitamin D status and bone mass according to vitamin D-binding protein genotypes
Issued Date
2015
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Language
eng
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Mahidol University
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BioMed Central
Bibliographic Citation
Nutrition Journal. Vol. 14, (2015), 29
Suggested Citation
Hataikarn Nimitphong, Chanika Sritara, La-or Chailurkit, Suwannee Chanprasertyothin, Wipa Ratanachaiwong, Piyamitr Sritara, Boonsong Ongphiphadhanakul Relationship of vitamin D status and bone mass according to vitamin D-binding protein genotypes. Nutrition Journal. Vol. 14, (2015), 29. doi:10.1186/s12937-015-0016-1 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/2711
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Title
Relationship of vitamin D status and bone mass according to vitamin D-binding protein genotypes
Abstract
Background: Vitamin D-binding protein (DBP) may alter the biological activity of total 25-hydroxyvitamin D [25(OH)D];
this could influence on the effects of vitamin D in relation to bone mineral density (BMD) and fractures. Emerging data
suggest that fetuin-A may be involved in bone metabolism. We aimed to investigate the influence of DBP gene
polymorphism on the relationship of vitamin D status and fetuin-A levels to BMD and bone markers.
Methods: This cross-sectional study was part of a health survey of employees of the Electricity Generating Authority
of Thailand (1,734 healthy subjects, 72% male). Fasting blood samples were assayed for 25(OH)D, fetuin-A, N-terminal
propeptides of type 1 procollagen (P1NP), C-terminal cross-linking telopeptides of type I collagen (CTx-I), and DBP
rs2282679 genotypes. L1–L4 lumbar spine and femoral BMD were measured using dual-energy X-ray absorptiometry.
Results: The DBP rs2282679 genotype distribution conformed to the Hardy–Weinberg equilibrium. There were no
correlations between 25(OH)D levels and BMD and bone markers. But a trend of positive correlation was observed for
the DBP genotypes with total hip BMD, and for the interaction between 25(OH)D and DBP genotypes with BMD at all
femoral sites. We further analyzed data according to DBP genotypes. Only in subjects with the AA (common) genotype,
25(OH)D levels were positively related to BMD and bone markers, while fetuin-A was negatively related to total hip
BMD, independently of age, gender and BMI.
Conclusions: The interaction between vitamin D status, as measured by circulating 25(OH)D and DBP rs2282679
genotypes, modified the association between 25(OH)D and BMD and bone markers. Differences in DBP genotypes
additionally influenced the correlation of fetuin-A levels with femoral BMD.