Publication: Engineered production of kitasetalic acid, a new tetrahydro-β-carboline with the ability to suppress glucose-regulated protein synthesis
Issued Date
2018-10-01
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ISSN
18811469
00218820
00218820
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2-s2.0-85049596403
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Antibiotics. Vol.71, No.10 (2018), 854-861
Suggested Citation
Shohei Ueda, Shigeru Kitani, Takushi Namba, Masayoshi Arai, Haruo Ikeda, Takuya Nihira Engineered production of kitasetalic acid, a new tetrahydro-β-carboline with the ability to suppress glucose-regulated protein synthesis. Journal of Antibiotics. Vol.71, No.10 (2018), 854-861. doi:10.1038/s41429-018-0074-7 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/47295
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Title
Engineered production of kitasetalic acid, a new tetrahydro-β-carboline with the ability to suppress glucose-regulated protein synthesis
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Abstract
© 2018, The Author(s) under exclusive licence to the Japan Antibiotics Research Association. β-Carboline alkaloids and related compounds show a broad spectrum of biological activities. We previously identified new members of the β-carboline alkaloid family by using an engineered Kitasatospora setae strain and a heterologous Streptomyces host expressing the plausible biosynthetic genes, including the hypothetical gene kse_70640 (kslB). Here, we elucidated the chemical structure of a new tetrahydro-β-carboline compound (named kitasetalic acid) that appeared in a heterologous Streptomyces host expressing the kslB gene alone. Kitasetalic acid suppressed the expression of glucose-regulated protein 78 (GRP78) without inducing cell death. This is the first report to show that a tetrahydro-β-carboline compound regulates the expression of the GRP78 protein in cancer cell lines.