Publication: The global burden of sepsis: Barriers and potential solutions
Issued Date
2018-09-23
Resource Type
ISSN
1466609X
13648535
13648535
Other identifier(s)
2-s2.0-85053724139
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Critical Care. Vol.22, No.1 (2018), 123305059
Suggested Citation
Kristina E. Rudd, Niranjan Kissoon, DIrek Limmathurotsakul, Sotharith Bory, Birungi Mutahunga, Christopher W. Seymour, Derek C. Angus, T. Eoin West The global burden of sepsis: Barriers and potential solutions. Critical Care. Vol.22, No.1 (2018), 123305059. doi:10.1186/s13054-018-2157-z Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/46317
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Title
The global burden of sepsis: Barriers and potential solutions
Abstract
© 2018 The Author(s). Sepsis is a major contributor to the global burden of disease. The majority of sepsis cases and deaths are estimated to occur in low and middle-income countries. Barriers to reducing the global burden of sepsis include difficulty quantifying attributable morbidity and mortality, low awareness, poverty and health inequity, and under-resourced and low-resilience public health and acute health care delivery systems. Important differences in the populations at risk, infecting pathogens, and clinical capacity to manage sepsis in high and low-resource settings necessitate context-specific approaches to this significant problem. We review these challenges and propose strategies to overcome them. These strategies include strengthening health systems, accurately identifying and quantifying sepsis cases, conducting inclusive research, establishing data-driven and context-specific management guidelines, promoting creative clinical interventions, and advocacy.