Publication: Properties, metabolism and roles of sulfogalactosylglycerolipid in male reproduction
Issued Date
2018-10-01
Resource Type
ISSN
18732194
01637827
01637827
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2-s2.0-85052505361
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Mahidol University
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SCOPUS
Bibliographic Citation
Progress in Lipid Research. Vol.72, (2018), 18-41
Suggested Citation
Nongnuj Tanphaichitr, Kessiri Kongmanas, Kym F. Faull, Julian Whitelegge, Federica Compostella, Naoko Goto-Inoue, James Jules Linton, Brendon Doyle, Richard Oko, Hongbin Xu, Luigi Panza, Arpornrad Saewu Properties, metabolism and roles of sulfogalactosylglycerolipid in male reproduction. Progress in Lipid Research. Vol.72, (2018), 18-41. doi:10.1016/j.plipres.2018.08.002 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/45046
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Title
Properties, metabolism and roles of sulfogalactosylglycerolipid in male reproduction
Other Contributor(s)
Università degli Studi di Milano
University of Ottawa, Canada
University of California, Los Angeles
Università degli Studi del Piemonte Orientale Amedeo Avogadro, Novara
Queen's University, Kingston
Faculty of Medicine, Siriraj Hospital, Mahidol University
Nihon University
Ottawa Hospital Research Institute
University of Ottawa, Canada
University of California, Los Angeles
Università degli Studi del Piemonte Orientale Amedeo Avogadro, Novara
Queen's University, Kingston
Faculty of Medicine, Siriraj Hospital, Mahidol University
Nihon University
Ottawa Hospital Research Institute
Abstract
© 2018 Elsevier Ltd Sulfogalactosylglycerolipid (SGG, aka seminolipid) is selectively synthesized in high amounts in mammalian testicular germ cells (TGCs). SGG is an ordered lipid and directly involved in cell adhesion. SGG is indispensable for spermatogenesis, a process that greatly depends on interaction between Sertoli cells and TGCs. Spermatogenesis is disrupted in mice null for Cgt and Cst, encoding two enzymes essential for SGG biosynthesis. Sperm surface SGG also plays roles in fertilization. All of these results indicate the significance of SGG in male reproduction. SGG homeostasis is also important in male fertility. Approximately 50% of TGCs become apoptotic and phagocytosed by Sertoli cells. SGG in apoptotic remnants needs to be degraded by Sertoli lysosomal enzymes to the lipid backbone. Failure in this event leads to a lysosomal storage disorder and sub-functionality of Sertoli cells, including their support for TGC development, and consequently subfertility. Significantly, both biosynthesis and degradation pathways of the galactosylsulfate head group of SGG are the same as those of sulfogalactosylceramide (SGC), a structurally related sulfoglycolipid important for brain functions. If subfertility in males with gene mutations in SGG/SGC metabolism pathways manifests prior to neurological disorder, sperm SGG levels might be used as a reporting/predicting index of the neurological status.