Publication: Effects of different antimalarial drugs on gametocyte carriage in P. vivax malaria
Issued Date
2008-09-01
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ISSN
00029637
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2-s2.0-51949096026
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Mahidol University
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SCOPUS
Bibliographic Citation
American Journal of Tropical Medicine and Hygiene. Vol.79, No.3 (2008), 378-384
Suggested Citation
Sasithon Pukrittayakamee, Mallika Imwong, Pratap Singhasivanon, Kasia Stepniewska, Nicholas J. Day, Nicholas J. White Effects of different antimalarial drugs on gametocyte carriage in P. vivax malaria. American Journal of Tropical Medicine and Hygiene. Vol.79, No.3 (2008), 378-384. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/19291
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Title
Effects of different antimalarial drugs on gametocyte carriage in P. vivax malaria
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Abstract
The gametocytocidal and asexual stage activities of eight antimalarial and eight antibiotic-containing regimens were evaluated in 349 adult patients with P. vivax malaria. Gametocytemia was found in 63% of patients (22% before and 41% after treatment). The median (range) gametocyte clearance time was 24 hours (range, 2-504 hours) and correlated with asexual parasite clearance time (r = 0.52, P < 0.001). Gametocytemia in vivax malaria was more common in patients with admission parasitemia > 10,000/μL and after treatment with drugs which have weak antimalarial activity, and was also associated with an increased rate of vivax reappearance (29.4% versus 14.1%, P = 0.002). Sexual stage activities corresponded with asexual stage activity for all tested regimens. Treatment with potent antimalarial drugs reduces the transmission potential of P. vivax. Copyright © 2008 by The American Society of Tropical Medicine and Hygiene.