Publication: The 28-Day Mortality Outcome of the Complete Hour-1 Sepsis Bundle in the Emergency Department
Issued Date
2021-12-01
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15400514
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2-s2.0-85121957919
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Mahidol University
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SCOPUS
Bibliographic Citation
Shock (Augusta, Ga.). Vol.56, No.6 (2021), 969-974
Suggested Citation
Thidathit Prachanukool, Pitsucha Sanguanwit, Fuangsiri Thodamrong, Karn Suttapanit The 28-Day Mortality Outcome of the Complete Hour-1 Sepsis Bundle in the Emergency Department. Shock (Augusta, Ga.). Vol.56, No.6 (2021), 969-974. doi:10.1097/SHK.0000000000001815 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/77451
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Title
The 28-Day Mortality Outcome of the Complete Hour-1 Sepsis Bundle in the Emergency Department
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Abstract
INTRODUCTION: The Surviving Sepsis Campaign published the Hour-1 Sepsis Bundle in 2018. The first-hour management of patients with sepsis in the emergency department (ED) is important, as suggested in the Hour-1 Sepsis Bundle. The objectives of the present study were to evaluate 28-day mortality and delayed septic shock with use of a complete and incomplete Hour-1 Sepsis Bundle in the ED. METHODS: This prospective cohort study included adult patients with sepsis from March to July 2019. We followed the sepsis protocol used in the ED of a tertiary care hospital. RESULTS: We enrolled 593 patients, with 55.9% in the complete Hour-1 Sepsis Bundle group. The 28-day mortality was 3.9% overall and no significant difference between the complete and incomplete Hour-1 Sepsis Bundle groups (3.6% vs. 4.2%, P = 0.707). Complete Hour-1 Sepsis Bundle treatment was not associated with 28-day mortality (adjusted OR = 2.04, 95% confidence interval [CI] = 0.72-5.74, P = 0.176) or delayed septic shock (adjusted OR = 0.74, 95% CI = 0.30-1.78, P = 0.499). Completion of each bundle did not affect outcomes of 28-day mortality and delayed septic shock. CONCLUSIONS: The complete Hour-1 Sepsis Bundle treatment in the ED was not significantly associated with 28-day mortality and delayed septic shock. TRIAL REGISTRATION: The trial was registered in the Thai Clinical Trial Registry, TCTR 20200526013.