Publication: The effects of antiretroviral dose modification on the re-emergence of HIV-1 wild-type strains.
Issued Date
2002-03-01
Resource Type
ISSN
01251562
Other identifier(s)
2-s2.0-0036491968
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Mahidol University
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SCOPUS
Bibliographic Citation
The Southeast Asian journal of tropical medicine and public health. Vol.33, No.1 (2002)
Suggested Citation
Ekachai Jenwitheesuk, Somsri Auswinporn, Asda Vibhagool, Wasun Chantratita The effects of antiretroviral dose modification on the re-emergence of HIV-1 wild-type strains.. The Southeast Asian journal of tropical medicine and public health. Vol.33, No.1 (2002). Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20525
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Title
The effects of antiretroviral dose modification on the re-emergence of HIV-1 wild-type strains.
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Abstract
Four human immunodeficiency virus type 1 (HIV-1) treatment-naïve Thai patients began antiretrovival therapy with a triple drug regimen -zidovudine plus lamivudine plus indinavir; this regimen was modified at week 20 of therapy because of drug toxicity. The virus in all patients was suppressed to lower than 400 copies/ml while they were taking the triple antiretroviral drug regimen. However, suppression was lost after changing the antiretroviral regimen. A comparison of HIV-1 DNA sequences taken from the baseline (day 0) and week 24 showed no significant overgrowth in HIV-1 drug-resistant strains. There was no difference in the protease and reverse transcriptase (RT) mutation profiles. Resistant variants did not emerge, even after sub-therapeutic levels of antiretroviral drugs had been introduced to these patients for 4 weeks. These findings may have clinical implications for long-term treatment strategies.