Publication: Rosa damascena oil improves SSRI-induced sexual dysfunction in male patients suffering from major depressive disorders: Results from a double-blind, randomized, and placebo-controlled clinical trial
Issued Date
2015-03-09
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ISSN
11782021
11766328
11766328
Other identifier(s)
2-s2.0-84929149597
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Mahidol University
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SCOPUS
Bibliographic Citation
Neuropsychiatric Disease and Treatment. Vol.11, (2015), 625-635
Suggested Citation
Vahid Farnia, Mehdi Shirzadifar, Jalal Shakeri, Mansour Rezaei, Hafez Bajoghli, Edith Holsboer-Trachsler, Serge Brand Rosa damascena oil improves SSRI-induced sexual dysfunction in male patients suffering from major depressive disorders: Results from a double-blind, randomized, and placebo-controlled clinical trial. Neuropsychiatric Disease and Treatment. Vol.11, (2015), 625-635. doi:10.2147/NDT.S78696 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/36493
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Title
Rosa damascena oil improves SSRI-induced sexual dysfunction in male patients suffering from major depressive disorders: Results from a double-blind, randomized, and placebo-controlled clinical trial
Abstract
© 2015 Farnia et al. Background: A substantial disadvantage of psychopharmacological treatment of major depressive disorder (MDD) with selective serotonin-reuptake inhibitors (SSRIs) is the impact on sexual dysfunction. The aim of the present study was to investigate whether the oil of Rosa damascena can have a positive influence on SSRI-induced sexual dysfunction (SSRI-I SD) of male patients who are suffering from MDD and are being treated with SSRIs.Method: In a double-blind, randomized, and placebo-controlled clinical trial, a total of 60 male patients treated with an SSRI and suffering from MDD (mean age =32 years) and SSRI-I SD were randomly assigned to take either verum (R. damascena oil) or a placebo. Patients completed self-ratings of depression and sexual function at baseline, at 4 weeks later, and at the end of the study, 8 weeks after it started.Results: Over time, sexual dysfunction improved more in the verum group than in the control group. Improvements were observed in the verum group from week 4 to week 8. Self-rated symptoms of depression reduced over time in both groups, but did so more so in the verum group than in the control group.Conclusion: This double-blind, randomized, and placebo-controlled clinical trial showed that the administration of R. damascena oil ameliorates sexual dysfunction in male patients suffering from both MDD and SSRI-I SD. Further, the symptoms of depression reduced as sexual dysfunction improved.