Publication: In vitro assessment of Ag-TiO<inf>2</inf>/polyurethane nanocomposites for infection control using response surface methodology
Issued Date
2017-08-01
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ISSN
13815148
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2-s2.0-85021290763
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Mahidol University
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SCOPUS
Bibliographic Citation
Reactive and Functional Polymers. Vol.117, (2017), 120-130
Suggested Citation
Phasinee Khwanmuang, Porpon Rotjanapan, Angsana Phuphuakrat, Sirawat Srichatrapimuk, Chayanisa Chitichotpanya In vitro assessment of Ag-TiO<inf>2</inf>/polyurethane nanocomposites for infection control using response surface methodology. Reactive and Functional Polymers. Vol.117, (2017), 120-130. doi:10.1016/j.reactfunctpolym.2017.06.012 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/41820
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Title
In vitro assessment of Ag-TiO<inf>2</inf>/polyurethane nanocomposites for infection control using response surface methodology
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Abstract
© 2017 Elsevier B.V. Combining the use of a central composite design (CCD) with a response surface methodology (RSM), Ag-TiO2/Polyurethane (PU) nanocomposites with superior antimicrobial activities and minimal color changes were developed and optimized for self-disinfecting coating. An experimental design was utilized to assess the effects of two independent variables: 1) AgNO3content and 2) TiO2content on four measured responses, i.e., the reduction of E. coli and S. aureus, color differences, and the amount of Ag+release of nanocomposites. The nanocomposites were characterized by Transmission Electron Microscope, and X-ray diffraction. To validate the optimal conditions for real clinical applications for Ramathibodi Hospital (Bangkok, Thailand), the performance evaluations of the coatings such as cytotoxicity test and color differences were conducted, and the antibacterial activities were tested against seven key strains of antibiotic-resistant bacteria. The result suggested that this formulation has high potential for self-disinfecting coating applications.