Publication: Allahabadolactones A and B from the endophytic fungus, Aspergillus allahabadii BCC45335
Issued Date
2016-01-28
Resource Type
ISSN
14645416
00404020
00404020
Other identifier(s)
2-s2.0-84952049950
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Mahidol University
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SCOPUS
Bibliographic Citation
Tetrahedron. Vol.72, No.4 (2016), 489-495
Suggested Citation
Karoon Sadorn, Siriporn Saepua, Nattawut Boonyuen, Pattiyaa Laksanacharoen, Pranee Rachtawee, Samran Prabpai, Palangpon Kongsaeree, Pattama Pittayakhajonwut Allahabadolactones A and B from the endophytic fungus, Aspergillus allahabadii BCC45335. Tetrahedron. Vol.72, No.4 (2016), 489-495. doi:10.1016/j.tet.2015.11.056 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/43189
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Title
Allahabadolactones A and B from the endophytic fungus, Aspergillus allahabadii BCC45335
Abstract
© 2015 Elsevier Ltd. All rights reserved. Two new compounds, allahabadolactones A (1) and B (2), along with 10 known compounds including 16-amino-isopimar-7-en-19-oic acid (3), 16-α-d-glucopyranosyloxyisopimar-7-en-19-oic acid (4), 16-α-d-mannopyranosyloxyisopimar-7-en-19-oic acid (5), ergosterol, (22E)-5α,8α-epidioxyergosta-6,22-dien-3β-ol, cerevisterol, (R)-(-)-methoxycarbonylmellein, (-)-piliformic acid, 7-dechlorogriseofulvin, and cytochalasin D, were isolated from the endophytic fungus, Aspergillus allahabadii BCC45335. Their chemical structures were determined based on NMR spectroscopic and mass spectrometric analyses. The absolute stereochemistry of compound 1 was established by an X-ray crystallographic analysis and the reactions with Mosher's reagents. A plausible biosynthesis of allahabadolactones A (1) and B (2) was also proposed. Antibacterial activity against Bacillus cereus and cytotoxicity against MCF-7, KB, NCI-H187, and Vero cells of the isolated compounds were also evaluated.