Publication: Rate of CD4 Decline and Factors Associated with Rapid CD4 Decline in Asymptomatic HIV-Infected Patients
Issued Date
2016-01-01
Resource Type
ISSN
23259582
23259574
23259574
Other identifier(s)
2-s2.0-84953316686
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the International Association of Providers of AIDS Care. Vol.15, No.1 (2016), 3-6
Suggested Citation
Natdanai Chaiyasin, Somnuek Sungkanuparph Rate of CD4 Decline and Factors Associated with Rapid CD4 Decline in Asymptomatic HIV-Infected Patients. Journal of the International Association of Providers of AIDS Care. Vol.15, No.1 (2016), 3-6. doi:10.1177/2325957415616493 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/40887
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Title
Rate of CD4 Decline and Factors Associated with Rapid CD4 Decline in Asymptomatic HIV-Infected Patients
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Abstract
© The Author(s) 2014. The accurate marker to assess the risk of disease progression in HIV disease is CD4 count. CD4 decline to <200 cells/mm3 prompts the patients to have risk of opportunistic infections. A retrospective cohort study was conducted in asymptomatic HIV-infected patients who had CD4 count >200 cell/mm3, were antiretroviral naive, and had ≥1-year follow-up. Eighty patients, with mean age of 36.4 (standard deviation [SD] = 9.1) years and 58.8% females, were analyzed. The mean (SD) baseline CD4 count was 423 (119) cells/mm3. During the median (IQR) time of 29.0 (14.1-49.6) months, 26.3% had CD4 declined to <200 cells/mm3. From Cox proportional hazard model, only baseline CD4 count <350 cells/mm3 was significantly associated with rapid decline in CD4 count (HR 4.208; 95%CI, 1.428-12.397; P =.009). Age, gender, comorbid disease, risk of HIV infection, duration of HIV diagnosis, and body weight were not associated with rapid CD4 decline. This indicates that asymptomatic patients with CD4 count <350 cells/mm3 are at priority for antiretroviral therapy in resource-limited settings.