Publication: Combined pulmonary tuberculosis with pulmonary and pleural cryptococcosis in a patient receiving ruxolitinib therapy
Issued Date
2021-01-01
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ISSN
11786973
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2-s2.0-85117733050
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Mahidol University
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SCOPUS
Bibliographic Citation
Infection and Drug Resistance. Vol.14, (2021), 3901-3905
Suggested Citation
Akarawut Kasemchaiyanun, Thitiporn Suwatanapongched, Pimpin Incharoen, Sirithep Plumworasawat, Jackrapong Bruminhent Combined pulmonary tuberculosis with pulmonary and pleural cryptococcosis in a patient receiving ruxolitinib therapy. Infection and Drug Resistance. Vol.14, (2021), 3901-3905. doi:10.2147/IDR.S327821 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/78582
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Title
Combined pulmonary tuberculosis with pulmonary and pleural cryptococcosis in a patient receiving ruxolitinib therapy
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Abstract
With an advance in therapy, there are increasing emerging and re-emerging opportunistic infections among patients with hematologic conditions and malignancy. Herein, we present a 56-year-old woman with primary myelofibrosis who developed combined tuberculosis (TB) and cryptococcosis with extensive pulmonary, pleural, and nodal involvement during ruxolitinib therapy. Marked clinical and radiologic improvements were undoubtedly evident after receiving anti-TB and antifungal therapies and pleural drainage. Hence, the presence of atypical clinical and radiologic manifestations and incomplete responses, despite receiving adequate antimicrobial treatment, should raise concerns regarding the combined emerging and re-emerging opportunistic infections and the possibility of unusual radiologic manifestations of cryptococcosis in a ruxolitinib-treated patient.