Publication: Biological activity of dolichandrone serrulata flowers and their active components
Issued Date
2015-01-01
Resource Type
ISSN
15559475
1934578X
1934578X
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2-s2.0-84945995793
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Mahidol University
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SCOPUS
Bibliographic Citation
Natural Product Communications. Vol.10, No.8 (2015), 1387-1390
Suggested Citation
Phanida Phanthong, Noppawan Phumala Morales, Sirirat Chancharunee, Supachoke Mangmool, Natthinee Anantachoke, Nuntavan Bunyapraphatsara Biological activity of dolichandrone serrulata flowers and their active components. Natural Product Communications. Vol.10, No.8 (2015), 1387-1390. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/35250
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Title
Biological activity of dolichandrone serrulata flowers and their active components
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Abstract
Dolichandrone serrulata (DC.) Seem flowers are widely used as vegetables in northern and eastern Thailand. Biological studies of the methanolic extract of these flowers have shown promising antioxidant activity. Biological-guided separation of D. serrulata flowers yielded six compounds, identified as hallerone, protocatechuic acid, rengyolone, cleroindicin B, ixoside, and isomaltose. This is the first report on hallerone, protocatechuic acid, rengyolone, cleroindicin B, and isomaltose in D. serrulata. Protocatechuic acid was the most potent scavenger of 2,2-diphenyl-l-picrylhydrazyl and hydroxyl radicals with IC50values of 25.6 ± 0.6 and 29.6 ± 0.4 μM, respectively. Hallerone and rengyolone showed moderate scavenging action on superoxide radicals and inhibited H2O2induced reactive oxygen species production in HEK-293 cell. In addition, the other isolated compounds showed weak activity.