Publication: Reduction of plasma cholesterol by Curcuma comosa extract in hypercholesterolaemic hamsters
1
Issued Date
1999-08-01
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ISSN
03788741
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2-s2.0-0033057056
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Ethnopharmacology. Vol.66, No.2 (1999), 199-204
Suggested Citation
Pawinee Piyachaturawat, Jinda Charoenpiboonsin, Chaivat Toskulkao, Apichart Suksamrarn Reduction of plasma cholesterol by Curcuma comosa extract in hypercholesterolaemic hamsters. Journal of Ethnopharmacology. Vol.66, No.2 (1999), 199-204. doi:10.1016/S0378-8741(98)00170-6 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/25783
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Title
Reduction of plasma cholesterol by Curcuma comosa extract in hypercholesterolaemic hamsters
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Abstract
The influence of the extract of Curcuma comosa Roxb. (Zingiberaceae) on lipid metabolism was investigated in hypercholesterolaemic hamsters. Intragastric administration of the ethyl acetate extract of C. comosa rhizome (0-500 mg/kg per day) to hypercholesterolaemic animals for 7 days decreased both plasma triglyceride and cholesterol levels in a dose-dependent manner. The reduction of plasma cholesterol levels was accompanied by a significant increase in the hepatic cholesterol content while the triglyceride content was not significantly changed. The increase of the hepatic cholesterol content was brought about by an expansion of the free cholesterol pool which specifically augments biliary cholesterol excretion. The C. comosa extract also increased plasma high density lipoprotein (HDL)-cholesterol and decreased plasma low density lipoprotein (LDL)-cholesterol. These results suggest that the C. comosa extract exerts a hypolipidaemic action by acceleration of lipid mobilization from extrahepatic tissue to the liver which subsequently increases excretion of cholesterol via the bile for excretion.