Publication: Synthesis of oligosaccharide fragments of capsular polysaccharide Staphylococcus aureus type 8
1
Issued Date
2020-01-01
Resource Type
ISSN
15322327
07328303
07328303
Other identifier(s)
2-s2.0-85091345480
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Carbohydrate Chemistry. (2020)
Suggested Citation
Satsawat Visansirikul, Stephen A. Kolodziej, Alexei V. Demchenko Synthesis of oligosaccharide fragments of capsular polysaccharide Staphylococcus aureus type 8. Journal of Carbohydrate Chemistry. (2020). doi:10.1080/07328303.2020.1821042 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/58997
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Synthesis of oligosaccharide fragments of capsular polysaccharide Staphylococcus aureus type 8
Other Contributor(s)
Abstract
© 2020 Taylor & Francis Group, LLC. To enhance our understanding of the activation and conjugation processes, reported herein is the synthesis of oligosaccharides comprising two sequential repeating units of capsular polysaccharide S. aureus serotype 8 (CP8). As in our previous syntheses of staphylococcal oligosaccharides, the potential propagation positions are blocked with methyl groups. While protein conjugates of carbohydrate antigens based on the structure of the S. aureus capsular serotypes have the potential to contribute to a S. aureus vaccine, despite promising preclinical data, efficacy has not been detected in human populations thus far.