Publication: Cell-Derived Microparticles in Blood Products from Blood Donors Deficient in Glucose-6-Phosphate Dehydrogenase
Issued Date
2021-11-02
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19437730
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2-s2.0-85106349175
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Mahidol University
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SCOPUS
Bibliographic Citation
Laboratory medicine. Vol.52, No.6 (2021), 528-535
Suggested Citation
Egarit Noulsri, Surada Lerdwana, Duangdao Palasuwan, Attakorn Palasuwan Cell-Derived Microparticles in Blood Products from Blood Donors Deficient in Glucose-6-Phosphate Dehydrogenase. Laboratory medicine. Vol.52, No.6 (2021), 528-535. doi:10.1093/labmed/lmab007 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/75963
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Title
Cell-Derived Microparticles in Blood Products from Blood Donors Deficient in Glucose-6-Phosphate Dehydrogenase
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Abstract
OBJECTIVE: To quantitate the microparticles (MPs) in whole blood and blood products obtained from blood donors who are deficient in glucose-6-phosphate dehydrogenase (G6PD). METHODS: The current study analyzed whole blood and blood components prepared from 49 blood donors with G6PD deficiencies and 98 with G6PD-normal results. Packed red blood cells (PRBCs), platelet concentrate (PC), and plasma were prepared according to transfusion laboratory procedures. MP concentrations were determined using a flow cytometer. RESULTS: Blood components prepared from donors with G6PD deficiency were characterized by higher red blood cell-derived MP (RMP) concentration in PRBCs (25,526 vs 18,738 particles/µL) but lower concentrations of platelet-derived MPs (PMPs; in whole blood and PC), leukocyte-derived MPs (LMP; in whole blood and plasma) and total MP (in PC), compared with those from donors with G6PD-normal test results. CONCLUSIONS: These results suggest that differences in G6PD status may account for variation in RMP levels during processing.