Publication: Orthostatic hypotension is associated with new-onset atrial fibrillation: Systemic review and meta-analysis
Issued Date
2019-07-01
Resource Type
ISSN
22133763
00194832
00194832
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2-s2.0-85071861935
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Mahidol University
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SCOPUS
Bibliographic Citation
Indian Heart Journal. Vol.71, No.4 (2019), 320-327
Suggested Citation
Narut Prasitlumkum, Jakrin Kewcharoen, Natthapon Angsubhakorn, Pakawat Chongsathidkiet, Pattara Rattanawong Orthostatic hypotension is associated with new-onset atrial fibrillation: Systemic review and meta-analysis. Indian Heart Journal. Vol.71, No.4 (2019), 320-327. doi:10.1016/j.ihj.2019.07.009 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/51573
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Title
Orthostatic hypotension is associated with new-onset atrial fibrillation: Systemic review and meta-analysis
Abstract
© 2019 Cardiological Society of India Introduction: Orthostatic hypotension (OH) is common among elderly patients. Its presence may herald severe underlying comorbidities and be associated with a higher risk of mortality. Interestingly, recent studies suggest that OH is associated with new-onset atrial fibrillation (AF). However, a systematic review and meta-analysis of the literature has not been performed. We assessed the association between AF and OH through a systematic review of the literature and a meta-analysis. Methods: We comprehensively searched the databases of MEDLINE and EMBASE from inception to November 2018. Published prospective or retrospective cohort studies that compared new-onset AF between male patients with and without OH were included. Data from each study were combined using the random-effects, generic inverse-variance method of DerSimonian and Laird to calculate risk ratios and 95% confidence intervals. Results: Four studies from October 2010 to March 2018 were included in the meta-analysis involving 76,963 subjects (of which 3318 were diagnosed with OH). The presence of OH was associated with new-onset AF (pooled risk ratio 1.48; 95% confidence interval [1.21, 1.81], p?< 0.001; I2 = 69.4%). In hypertensive patients, analysis revealed an association between OH and the occurrence of new-onset AF (OR 1.46; 95% CI [1.27, 1.68], p < 0.001 with I2 = 0). Conclusions: OH was associated with new-onset AF up to 1.5-fold compared with those subjects without OH. The interplay between OH and AF is likely bidirectional.