The in vitro and ex vivo antioxidant properties, hypolipidaemic and antiatherosclerotic activities of water extract of Moringa oleifera Lam. leaves

dc.contributor.authorPilaipark Chumarken_US
dc.contributor.authorPanya Khunawaten_US
dc.contributor.authorYupin Sanvarindaen_US
dc.contributor.authorSrichan Phornchirasilpen_US
dc.contributor.authorNoppawan Phumala Moralesen_US
dc.contributor.authorLaddawal Phivthong-ngamen_US
dc.contributor.authorPiyanee Ratanachamnongen_US
dc.contributor.authorSupath Srisawaten_US
dc.contributor.authorK. u S Pongrapeepornen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherSrinakharinwirot Universityen_US
dc.contributor.otherThe Princess of Narathiwat Universityen_US
dc.description.abstractMoringa oleifera is used in Thai traditional medicine as cardiotonic. Recent studies demonstrated its hypocholesterolaemic effect. However, to be clinically useful, more scientific data are needed. Aim of the Study: We investigated the antioxidant, hypolipidaemic and antiatherosclerotic activities of Moringa oleifera leaf extract. Materials and Methods: Scavenging activity of the extract on 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH), and the inhibitory effect on Cu2+-induced low-density lipoprotein (LDL) oxidation were determined in in vitro experiment. The effects of the extract on cholesterol levels, conjugated diene (CD) and thiobarbituric acid reactive substances (TBARS) and plaque formations in cholesterol-fed rabbits were investigated. Results: We found that in scavenging DPPH radicals the extract and Trolox®had IC50of 78.15 ± 0.92 and 2.14 ± 0.12 μg/ml, respectively. The extract significantly (P < 0.05) prolonged the lag-time of CD formation and inhibited TBARS formation in both in vitro and ex vivo experiments in a dose-dependent manner. In hypercholesterol-fed rabbits, at 12 weeks of treatment, it significantly (P < 0.05) lowered the cholesterol levels and reduced the atherosclerotic plaque formation to about 50 and 86%, respectively. These effects were at degrees comparable to those of simvastatin. Conclusions: The results indicate that this plant possesses antioxidant, hypolipidaemic and antiatherosclerotic activities and has therapeutic potential for the prevention of cardiovascular diseases. © 2007 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.citationJournal of Ethnopharmacology. Vol.116, No.3 (2008), 439-446en_US
dc.rightsMahidol Universityen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleThe in vitro and ex vivo antioxidant properties, hypolipidaemic and antiatherosclerotic activities of water extract of Moringa oleifera Lam. leavesen_US