Publication: The correlation of β-subunit human chorionic gonadotropin level in the serum and first morning urine of patients with gestational trophoblastic disease
Issued Date
2001-07-01
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ISSN
01252208
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2-s2.0-0035405475
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.84, No.7 (2001), 1000-1005
Suggested Citation
Mongkol Benjapibal, Sansanee Senawong, Issaracha Suphanit, Tuangsit Wataganara, Dittakarn Boriboonhirunsarn The correlation of β-subunit human chorionic gonadotropin level in the serum and first morning urine of patients with gestational trophoblastic disease. Journal of the Medical Association of Thailand. Vol.84, No.7 (2001), 1000-1005. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/26744
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Title
The correlation of β-subunit human chorionic gonadotropin level in the serum and first morning urine of patients with gestational trophoblastic disease
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Abstract
The purpose of this cross-sectional study was to determine the correlation of beta subunit human chorionic gonadotropin (β-hCG) level in the serum and first morning urine samples of patients with gestational trophoblastic disease (GTD). A total of 81 paired serum and first morning urine samples from 24 patients diagnosed with GTD, who had their follow-up at the Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University. The paired serum and first morning urine samples were measured for β-hCG level, using enzyme-linked immunosorbent assay (ELISA). After logarithmic transformation, serum β-hCG level was strongly and significantly correlated to those of first morning urine samples, with the correlation coefficient of 0.97 (p < 0.01). Among the disease-remission group (serum β-hCG of less than 5 mIU/ml), the correlation coefficient was 0.52 (p < 0.01), which was still statistically significant. Stronger statistical significance was found in the disease-active group (serum β-hCG of 5 mIU/ml or higher), with the correlation coefficient of 0.95 (p < 0.01). We concluded that the level of serum β-hCG was strongly and significantly correlated with those of first morning urine samples, especially in patients with active disease. Determination of β-hCG level using first morning urine samples can be used as an effective mean in the follow-up of patients with GTD.