Publication: Evidence suggesting a genetic contribution to kidney stone in northeastern Thai population
Issued Date
2009-06-01
Resource Type
ISSN
03005623
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2-s2.0-67650070986
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Mahidol University
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SCOPUS
Bibliographic Citation
Urological Research. Vol.37, No.3 (2009), 141-146
Suggested Citation
Suchai Sritippayawan, Sombat Borvornpadungkitti, Atchara Paemanee, Chagkrapan Predanon, Wattanachai Susaengrat, Duangporn Chuawattana, Nunghathai Sawasdee, Sirintra Nakjang, Suttikarn Pongtepaditep, Choochai Nettuwakul, Nanyawan Rungroj, Somkiat Vasuvattakul, Prida Malasit, Pa Thai Yenchitsomanus Evidence suggesting a genetic contribution to kidney stone in northeastern Thai population. Urological Research. Vol.37, No.3 (2009), 141-146. doi:10.1007/s00240-009-0189-1 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/28072
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Title
Evidence suggesting a genetic contribution to kidney stone in northeastern Thai population
Abstract
Genetic factor may play a role in the pathogenesis of kidney stone that is found in the northeastern (NE) Thai population. Herein, we report initial evidence suggesting genetic contribution to the disease in this population. We examined 1,034 subjects including 135 patients with kidney stone, 551 family members, and 348 villagers by radiography of kidney-ureter-bladder (KUB) and other methods, and also analyzed stones removed by surgical operations. One hundred and sixteen of 551 family members (21.05%) and 23 of the 348 villagers (6.61%) were affected with kidney stone. The relative risk (λR) of the disease among family members was 3.18. Calcium stones (whewellite, dahllite, and weddellite) were observed in about 88% of stones analyzed. Our data indicate familial aggregation of kidney stone in this population supporting that genetic factor should play some role in its pathogenesis. Genetic and genomic studies will be conducted to identify the genes associated with the disease. © 2009 Springer-Verlag.